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《Carcinogenesis,Teratogenesis and Mutagenesis》 1992-02
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IS FURANCOL GENRALLY RECOGNIZED AS SAFE?

LiXili, Shang Reiming, Shen Juen, Sun Haodong Division of Toxicology, Tianjin Medical College, Tian jin 300070  
Furancol is a flavor extractod from pineapple in 1965 and generally recognized as safe(GRAS)for direct addition to human foods, tobaccos, soft drinks,cosmatics and pharmaceutical industry. It's Code NO. is FEMA: 3174; COE: 536. Xing (1988)found that it was mutagonic in several short-term test systems. In present paper we found it was mutagenic once more in SOS chromotest Rec-Assey and teratogenic in rapid assessment of Drosophila Melanogaster Oregon Kstrain. Our laboratory call on attention of the importance of doing further mutagenicity and teratogenicity test on furancol.
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