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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1999-02
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A STUDY ON THE ANTIMUTAGENICITY OF CHEMICAL COMPOUNDS EXTRACTED FROM CNIDIUM MONNIERI(L) CUSS USED IN CHINESE TRADITIONAL MEDICINE

Yin Xuejun\+1, Xiang Rende\+2, Liu Dexiang\+1, Zhang Xinyong\+2, Xu Yonghua\+1, Han Ying\+2, Wang Rui\+1, Wang Hechuan\+1 \+1 Institute of Clinical Medicine, Urumqi General Hospital of Lanzhou Command, PLA, Urumqi\ 830000, \+2 Nanjing Institute of Mater  
The antimutagenicity of 9 kinds of chemical compounds (osthol, Bergaten, Isopimpinellin, Imperatorin, Xanthotoxol, Xnthotoxin, Thymine, Uracil and unknown one that need authenticating) was studied with the Ames test and the micronucleus and chromosomal aberretion assays in mice in vivo. These compounds were isolated from the water extract of Cnidium monnieri (L.) Cuss in Chinese traditional medicine. The results showed that osthol., bergapten, isopimpinellin, imperatorin, xanthotoxol and xanthotoxin had inhibited activity of mutagenicity of aflatoxin B\-1. And osthol, bergapten, isopimpinellin, imperatorin also had high activity in inhibiting the chromosomal aberrations and micronuclei that induced by cyclophosphamid in vivo. The other three compounds (Thymine, Uracil and unknown one that need authenticating) showed no antimutagenicity.
【Fund】: 国家自然科学基金! NO:29372053
【CateGory Index】: R285
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