A STUDY ON THE MECHANISM OF ANTIMUTAGENESIS OF TURMERIC OIL
Zhao Zezhen\+1, Wen Denggui\+1, Wei Lizhen\+1 and Di Hailing\+2 \+1 Hebei Cancer Institute, Shijiazhuang 050011, \+2The Third Hospital Of Hebei Medical University
To understand the mechanism of mutagenesis inhibitory effect of Turmeric oil, the authors designed a series of testing procedures to examine the inhibitory effect by Turmeric oil on the mutagenesis induced by Mitomycine(MMC) in Escherichia Coil lysogenic strain of GY5027 as indicated by GY4015 as following ways: A. GY5027 was added after Turmeric oil and MMC had been put together for 20 minutes. B. Turmeric oil was added after GY5027 had been treated with MMC for 20 minutes. C. MMC was added after GY5027 had been treated with Turmeric oil for 20 minutes. D. GY5027, Turmeric oil and MMC were put into together at the same time. Results found that in all of the above A, B, C and D experimental designs, the mutagnesis was significantly inhibited by Turmeric oil. This indicates that Turmeric oil might be able to inhibit mutagenesis both intercellularly and extracellularly and repair genetic damages caused by genotoxicant.