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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1999-02
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INHIBITORY EFFECT OF LAMINARIA JAPONICA POLYSACCHARIDES ON MICRONUCLEUS RATE INDUCED BY CYCLOPHOSPHAMIDE IN MICE

Wang Tingxin, Qin Shuzheng, Zhao wen, Jiang Dongsheng, Ma Xiaotong, Bian Qiangrong HeBei Sanitary Epidemic Station, Baoding\ 071000  
Inhibitory effect of Laminaria japonica polysacchrides (LPS) on micronucleus rate induced by cyclophosphamide (CP) had been studied by mean of micronucleus test in mouse bone marrow polychromatic erythrocyte (PCE). Micronucleus rates of positive control group (CP 40mg/kg.bw), and three LPS tested groups (LPS 500mg/kg, 1000mg/kg, 2000mg/kg) was 28‰, 22‰, 12‰, 11‰, respectively. There were significant differences tested groups (1000mg/kg, 2000mg/kg) as compared with positive control group. The results showed that LPS possessed inhibitory effects on mutagenesis indued by cyclophamide.
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