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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 1999-05
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USE IN VIVO MULTIPLE ENDPOINTS ASSAY FOR STUDYING ESTROGENICITY OF ENDOSULFAN

Qiu Jiongliang, Chang Yan, Zhu Xinqiang Department of Toxicology, Zhejiang University, Hangzhou\ 310006  
We combined five endpoints into a single 5 day in vivo screening assay to identify estrogenicity of endosulfan. The endpoints evaluated as markers of esrogenicity included the ratio of uterine weight/body weight, uterine fluid imbibition, vaginal cornification incidence, uterine stroma cell proliferation and uterine epithelial cell height. The endosulfan were administered daily p.o. for 5 days to sexually mature ovariectomized female NIH mice. Compared with the five endpoints of the three dosage groups of edosulfan (0.5mg/kg/d,1.5mg/kg/d and 3.0 mg/kg/d) showed no significant difference and no significant dose response. Thus, endosulfan has no estrogenicity under the experimental condition.
【Fund】: 国家自然科学基金
【CateGory Index】: R996
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