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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 2000-01
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STUDY ON IN VITRO ANTIMUTAGENICITY OF ETHANOL EXTRACT OF SCORPION

WU Jin long, WANG Li yun (Jiangsu Provincial Anti epidemic and Hygienic Station, Nanjing\ 210009, China)  
Purpose and Methods: Antimutagenicity of ethanol extract of scorpion and some Chinese medicinal herbs(SEE) was investigated using a Salmonella typhimurium/mammalian microsome assay in the paper. Results:At 25-100μl/plate, SEE had no effect on TA98 revertants induced by the utimate mutagen, Dexon and neither on TA100 revertants by the ultimate mutagen, sodium azide(NaN\-3). But the revertants of TA98 induced by promutagen, 2-aminofluorence(2-AF) was significantly inhibited by SEE at same dosage. The relative revertants of TA98 were 1985±483\,1232±176 and 792±170 respectively at 25μl/plate, 50μl/plate and 100μl/plate of SEE with 15μg/plate of 2-AF. In comparasion with positive control (3182±784), the relative revertants at 25μl/plate\,50μl/plate and 100μl/plate had significant and very significant statistical difference (P0.05 and P0.01) and the inhibitory percentages of the relative revertants were 38.06%, 61.90% and 75.11% respectively. It was obvious that the increase of inhibitory percentages deponded upon the dose of SEE.Conclusion: These results indicated that SEE was a possible inhibitor of 2-AF. Antimutagenicity of SEE toward 2-AF could be attributed primarily to the effect of SEE on S\-9 mixture.
【CateGory Index】: R99
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