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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 2000-02
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THE SITUATION OF DNA SYNTHESIS、 DNA DAMAGE AND DNA REPAIR IN ARSENISM PATIENTS BLOOD CELLS CAUSED BY COAL-BURNING

ZHANG Ai-hua, YANG Guang-hong, LI Jian, WANG Rong Department of Prevetive Medicine, Guiyang Medical College, Guiyang 550004, China  
Purpose and Methods:Using liquid scintillation count assay and 125 I postlabeling assay, DNA spontaneous synthesis、 DNA protein crosslinks (DPC) and unscheduled DNA synthesis(UDS) were detected to study DNA synthesis、 repair function and DNA damage condition in human peripheral blood cells of arsenism caused by burning coal. Results: The DNA synthesis of non patients and patients in local area obvious decreased, while DPC level increased with the development of poisoning, and UDS increased only in the patients, the difference were all significant. Conclusion: It suggested that arsenic containing in coal might induce DPC in early stage and severely hurt DNA; and it might induce UDS, the DNA synthesis and repair ability were seriously restrained. It might be one of the reasons causing dermal cancer.
【Fund】: 国家自然科学基金! (396 6 0 0 70 )
【CateGory Index】: X503.1
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