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《CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS》 2000-03
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CELLULAR EFFECTS OF CYCLOPHOSPHAMIDE ON MOUSE EMBRYOS FROM WHOLE EMBRYO CULTURE SYSTEM

GUAN Xiao-ju, et al (Institute of Immunology, Third Military Medical University, Chongqing 400038, China)  
Purpose and Methods: By using mouse whole embryo culture technique, the in vitro model of cyclophosphamide-induced teratogenicity was established. The cellular effects of cyclophosphamide on mouse embryos was evaluated by light microscopy and flow cytometry. Results and Conclusion: The results suggested that the variation of cell cycle and the occurrence of apoptosis might be involved in cyclophosphamide-induced teratogenicity.
【CateGory Index】: R321
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