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《Carcinogenesis,Teratogenesis and Mutagenesis》 2001-01
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STUDY ON THE ANTIMUTAGENICTTY OF ORIDONIN

YANG Sheng-li, HAN Shao-yin, ZHANG Qiao, DING Lan-ping, SONG Ai-yun, GONG Ya-ou, ZHANG Tan-mu (Department of Esophageal Cancer Research, Henan Medical University, Zhengzhou 450052, China)  
Purpose: To study the antimutagenicity of Oridonin Methods: Ames test and micronucleus assay of polychromatic erythrocytes in mice bone marrow were used. Results: Oridonin could evidently inhibit the reverse mutation on Salmonella typhimuriun strains TA98 and TA100 without S9mix. The rates of maximum inhibition were 89.1% and 80.2% respectively. In addition, Oridonin could significantly reduce micronucleus frequencies induced by cyclophosphamide (P0.01). Conclusion: Oridonin has significant antimutagenic effect.
【Fund】: 国家自然科学基金资助项目!(3970 0 178)
【CateGory Index】: R285
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