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《Carcinogenesis,Teratogenesis and Mutagenesis》 2001-03
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DNA OXIDANT DAMAGE INDUCED BY TOBACCO SMOKE IN HUMAN BLOOD LYMPHOCYTES

MENG Zi qiang\+1, ZHANG Lian zhen\+2 (1. Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006,China; 2. China Institute for Radiation Protection, Taiyuan 030006, China)  
Purpose: To investigate the oxidative damage of DNA in human blood lymphocytes. Methods: Levels of 8 hydroxy 2 deoxyguanosine (8 OHdG) in human blood lymphocytes from healthy male smokers and non smokers were determined by high performance liquid chromatography system with an electrochemical detector. Results: (1)the mean level of 8 OHdG was significantly higher in smoker group than non smoker group, and a positive correlation between content of 8 OHdG and number of cigarette smoking per day was found; (2) A large interindividual variation in 8 OHdG levels was observed in smokers. Conclusion: Tobacco smoke can caused oxidant damage to DNA in human blood lymphocytes.
【CateGory Index】: R363
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【References】
Chinese Journal Full-text Database 7 Hits
1 WANG Wei 1,2 ,WU Yong-jun 1 ,WU Yi-ming 1,ˇ (1.Department of Occupational Health and Health Toxicology,College of Public Health,Zhengzhou University,Henan Zhengzhou450052, China;2.Zhengzhou Institute of Occupational Disease, Zhengzhou Henan450053,China);Genetic Polymorphism in hOGG1 and Susceptibility to Lung Cancer[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-02
2 LIU Hai-yun,TONG Jian,LI Jian-xiang*(Department of Health Toxicology,School of Radiology and Public Health,Medical College of Soochow University,Suzhou,Jiangsu 215123,China);Differences in Oxidative Damage and Gene Mutation between Smoking and Radon-induced Lung Cancer[J];Journal of Environmental & Occupational Medicine;2009-04
3 XU Nai-yu1,ZHANG Su-ping2,NIE Ji-hua2,et al(1.Department of Pharmacy,Suzhou University,Suzhou 215123 China;2.The Radiation and Public Health College of Suzhou University,The Key Laboratory of Radiation Medicine and Protection of Jiangsu Province,Suzhou 215123 China);Studies of Lymphatic Proteome of Rats exposed to Cigarette Smoke by Two-dimensional Gel Electrophoresis[J];Chinese Journal of Hemorheology;2007-02
4 LI Gui-rong,MA Yan-hui,ZHANG Ji,et al.(Department of Occupational and Environmental Health,School of Public Health,Peking University,Beijing,100083,China);A Study of Urinary 8-hydroxydeoxyguanosine(8-OHdG)as A Biomarker for Workers Exposed to Soluble Chromate[J];Preventive Medicine Tribune;2008-02
5 LIU Sheng-lin.(The Department of Examination,Xiqing Hospital in Tianjin,300380,China);The Progress of 8-hydroxy-2′-deoxyguanosine Detecting Method[J];Medical Recapitulate;2006-17
6 LIU Shan,SUN Gui fan,SUN Xian ce ,et al.School of Public Healt h,China Medical University(Shenyang 110000,China);DNA damage and repair of human lymphocytes treated with cigarette smoke solution[J];China Public Health;2004-01
7 Pan Hongzhi, Li Rong. Public Health School, Harbin Medical University, Harbin 150001, China;Detection of 8-hydroxy-2-deoryguanoslne,a marker for oxidative DNA damage[J];Chinese Journal of Health Laboratory Technology;2003-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 WANG Wei 1,2 ,WU Yong-jun 1 ,WU Yi-ming 1,ˇ (1.Department of Occupational Health and Health Toxicology,College of Public Health,Zhengzhou University,Henan Zhengzhou450052, China;2.Zhengzhou Institute of Occupational Disease, Zhengzhou Henan450053,China);Genetic Polymorphism in hOGG1 and Susceptibility to Lung Cancer[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-02
2 SONG Chun-ying, TAN Wen, LIN Dong-xin (Department of Etiology & Carcinogenesis, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P. R. China);Polymorphisms of DNA Repair Gene XRCC1 in Chinese Population and its Relation to Esophageal Squamous Cell Carcinoma[J];Chinese Journal of Cancer;2001-01
3 GE Shi li, LOU Tie zhu, XIANG Xiao qiong, CHEN Wei, WU De chang*Department of Molecular Toxicology, Beijing Institute of Radiation Medicine,Beijing 100850, P.R.China;Malignant Transformation of BEP2D Cell Induced by α Particles[J];Chinese Journal of Cancer;2001-09
4 ZHU Mao-xiang * ,YANG Zhi-hua,GONG Yi-fen,LU Ying,CAO Zhen-shan Institute of Radiatio n Medicine,Academy of Military Medical Science,B eijing 100850,P.R.Ch ina;Initiated Cancerazation Effect of Reactive Oxygen Species and Its Produ cts of Oxidative DNA Damage in B EP2D Cells[J];Chinese Journal of Cancer;2001-10
5 WANG Dong-hong, PENG An, WANG Zi-jian (State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China);ADVANCES IN STUDY OF HORMESIS[J];Journal of Safety and Environment;2004-01
6 LIU Ying,WANG Jing,WU Yiming,WU Yongjun.Department of Respiratory,the First Affiliated Hospital,Zhengzhou University,Zhengzhou 450052,Henan;Relationship between the expression of MGMT,K-ras in human nonsmall-cell lung cancer and their significance[J];Clinical Medicine;2006-03
7 JIN Yongtang , ZHOU Xiaotie, HE Xingzhou. Department of Environmental Health, Anhui Medical University, Hefei, Anhui 230032, P.R.China;The general measurement of genetic factors on lung cancer in Xuanwei, China[J];Chinese Journal of Lung Cancer;2001-05
8 Mei Surong 1,2 ,Xu Guowang *1 ,Wu Caiying 2 1(National Chromatographic Research and Analysis Center, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116011) 2(College of Chemistry, Wuhan University, Wuha;Analysis of 8-Hydroxydeoxyguanosine in Human Urine by Solid-phase Extraction and Derivatization Gas Chromatography[J];Chinese Journal of Analytieal Chemistry;2001-12
9 TONG Jian HONG Chengjiao WANG Jing FU Chunling (School of Nuclear Medicine, Soochow University, Suzhou 215007);STUDY ON DNA DAMAGE OF LYMPHOCYTES IN RATS EXPOSED TO RADON AND ITS PROGENY[J];Journal of Radiation Research and Radiation Processing;2001-03
10 SU Liaoyuan (Department of Medical Radiobiology, School of Radiation Medicine and Public Health, Soochow University, Suzhou 215007);ADVANCE OF STUDY ON HORMESIS OF LOW DOSE RADIATION[J];Journal of Radiation Research and Radiation Processing;2003-02
【Secondary References】
Chinese Journal Full-text Database 6 Hits
1 FU Gang SHEN Xiao-bing~* (School of Public Health,Southeast University,Nanjing 210009,China);Advances in the Relationship of DNA Repair Genetic Polymorphism and Gastric Cancer Susceptibility[J];Journal of Environmental & Occupational Medicine;2007-06
2 WANG Qin,XU Chun-yu,XU Dong-qun,et al. Institute for Environmental Health and Related Products Safety,China CDC,Beijing 100021,China;Polycyclic Aromatic Hydrocarbons Exposure and DNA Oxidative Damage in Traffic Policemen of Beijing[J];Journal of Environment and Health;2009-09
3 HUANG Tong,ZHAO Dan,CHEN Zhong-wei,et al.The Chronic Disease Prevention and Treatment Hospital of Nanshan District,Shenzhen Guangdong 518054,China.;Analysis of the situation of oxidation damnification of DNA of type 2 diabetic patients[J];Journal of Clinical and Experimental Medicine;2008-06
4 YANG Yuan, HU Changjun, TIAN He, HE Sheng Department of Clinical Laboratory, Huaihua Medical College, Huaihua 418000, China;Association of Human 8-Oxoguanine Glycosylase 1 Polymorphism with the Susceptibility of Laryngeal Cancer[J];Tianjin Medical Journal;2008-08
5 WU Wei1,2,YANG Jian1,2,QU Jianhong1,LIU Hongbo1,2,NIE Fengqin2 1.Freshwater Fisheries Research Center,Chinese Academy of Fishery Sciences;Key Laboratory of Inland Fishery Eco-environment and Resource,Chinese Academy of Fishery Sciences,Wuxi 214081,China;2.Fishery College,Nanjing Agriculture University,Wuxi 214081,China;Level of 8-hydroxy-2-deoxyguanosine in swan mussels Anodonta woodiana from Taihu Lake and its preliminary application to assess water pollution[J];Ecology and Environmental Sciences;2010-01
6 Zhang Deli Zhu Shengji Luo Guangfu Huang Yingping Yuan Ding Lui Liming (Center of Ecology & Environmental Science, China Three Gorges Univ.,Yichang 443002,China);Development of Free Radical-Induced Oxidative Damage to DNA[J];Journal of University of Hydraulic and Electric Engineering/yichang;2004-06
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