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《Carcinogenesis,Teratogenesis and Mutagenesis》 2002-02
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REPORT ON THE ANTIMUTAGENICITY AND ANTI-TUMOR ACTIVITY OF SIX KINDS OF CHINESE MEDICINAL HERBS

GUO Wei, ZHAO Ze-zhen, SHAN Bao-en, WEI Li-zhen, WEN Deng-gui(Hebei Cancer Institute, The 4+{th} Hospital of Hebei Medical University, Shijiazhuang 050011, China)  
Purpose: To test the antimutagenicity and anti-tumor activity of six kinds of Chinese medicinal herbs (hairyvein agrimony, hawthorn, mushroom, apricot kernel, jujube and isatis root). Methods: The antimutagenicity and mutagenicity of six kinds of Chinese medicinal herbs were investigated using the antimutagenicity and mutagenicity synchronous test, the anti-tumor activity of the six kinds of Chinese medicinal herbs to four kinds of tumor cells were investigated using in vitro anti-tumor test. Results: With and without rat liver microsomal enzymes (S9) the tests showed that all the Chinese medicinal herbs had no mutagenicity. Mushroom?howthorn?apricot kernel and jujube were antimutagen against MMC. Four different concentration groups of hairyvein agrimony?howthorn and mushroom extracts all had the effects of inhibiting the incorporation of+3H-TdR. The inhibition had an increasing tendency with the increasing of concentration. Conclusions: mushroom?hawthorn?apricot kernel and jujube have antimutagen activity, hairyvein agrimony?hawthorn and mushroom can apparently inhibit the synthesis of DNA of four kinds of tumor cells (MT-Ⅱ, L929, SKV20, K562).
【Fund】: 河北省中医药管理局资助课题 ( 980 46 )
【CateGory Index】: R73-36
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