INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY
LUO Peng+1, ZHANG Ai-hua+1, LI Jun+1, QING Du-cai+2, REN Yu-jiang+1, ZHAGN Bi-xia+2, WANG Xi-lan+1, HUANG Xiao-xing+2(1. Dept. of Preventive Medicine, Guiyang Medical College, Guiyang 550004, China; 2. 44th Hospital of PLA, Guiyang 550009, China)
Purpose: To observe the inhibitory effect of lithium carbonate (Li-2CO-3) on genetic and oxidative damage in cancer patients. Methods: The single cell gel electrophoresis assay (SCGE), micronucleus test were used to measure DNA and chromosomal damage. At the same time, SOD, GSH-Px, and-SH and MDA were detected by biochemical tests. Results: The genetic damage of peripheral blood cells in cancer patients was relieved gradually with Li-2CO-3 treatment, and the activity and content of the anti-oxidative material and WBC number increased significantly. Conclusion: Li-2CO-3 can inhibit genetic damage, increase the ability of anti-oxidation and relieve the myellogenic inhibition.