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《Carcinogenesis,Teratogenesis and Mutagenesis》 2002-02
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INHIBITORY EFFECT OF LITHIUM CARBONATE ON GENETIC AND OXIDATIVE DAMAGE IN CANCER PATIENTS WITH RADIOTHERAPY AND CHEMOTHERAPY

LUO Peng+1, ZHANG Ai-hua+1, LI Jun+1, QING Du-cai+2, REN Yu-jiang+1, ZHAGN Bi-xia+2, WANG Xi-lan+1, HUANG Xiao-xing+2(1. Dept. of Preventive Medicine, Guiyang Medical College, Guiyang 550004, China; 2. 44th Hospital of PLA, Guiyang 550009, China)  
Purpose: To observe the inhibitory effect of lithium carbonate (Li-2CO-3) on genetic and oxidative damage in cancer patients. Methods: The single cell gel electrophoresis assay (SCGE), micronucleus test were used to measure DNA and chromosomal damage. At the same time, SOD, GSH-Px, and-SH and MDA were detected by biochemical tests. Results: The genetic damage of peripheral blood cells in cancer patients was relieved gradually with Li-2CO-3 treatment, and the activity and content of the anti-oxidative material and WBC number increased significantly. Conclusion: Li-2CO-3 can inhibit genetic damage, increase the ability of anti-oxidation and relieve the myellogenic inhibition.
【Fund】: 贵州省自然科学基金 (G95 6 )
【CateGory Index】: R73-36
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【Citations】
Chinese Journal Full-text Database 5 Hits
1 ZHANG Zun-zhen, HENG Zheng-chang, LIAO Yan, ZHAO Rong (Department of Environment Health, West China University of Medical Sciences, Chengdu 610041,China);STUDY ON DNA DAMAGE INDUCED BY INDIRECT MUTAGENS USING COMET ASSAY IN TESTICULAR CELLS IN VITRO[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-01
2 Huang Xiaoxin, Zhang Aihua, Luo Peng, Wu Yingkuan, Jiang Xianyao Chinese People's Liberation Army 44th Hospital, Guiyang 550009;EFFECTS OF ANTITUMOR AND TOXIC AND SIDE RESPONSE OF LITHIUM CARBONATE ON CYCLOPHOSPHAMIDE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1998-02
3 Meng Ziqiang 1\ and Zhang Lianzhen 2 1\ Division of Environmental Biological Toxicology and Department of Life sciences, Shanxi University, Taiyuan 030006\ 2 China Institute for Radiation Protection, Taiyuan 030006;PRINCIPLE AND METHOD OF THE SINGLE CELL MICROGEL ELECTOPHORESIS (SCGE) TECHNIQUE TO STUDY DNA DAMAGE IN MAMMALIAN CELLS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1998-06
4 Zhang Aihua,Huang Xiaoxin,Luo Peng,Jiang Xianyao,et al. (Department of Public Health,Guiyang Medical College,Guiyang 550004,China);Study on Inhibition and Prevention of Tumor and Antioxidative Effects of Lithium Carbonate in Tumor Bearing Mice [J];JOURNAL OF HYGIENE RESEARCH;1998-02
5 LUO Peng,ZHANG Ai hua,HONG Feng,et al (Dept.of Prevention Medicine,Guiyang Medical College,Guiyang 550004,China) [;Study on lipid peroxidation and anti lipid peroxidation in the patients of arsenism caused by burning coal[J];CHINESE JOURANL OF CNDEMIOLOGY;2000-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LU Shuang+1, ZHANG Ai-hua+1, HUANG Xiao-xin+2, Ren Yu-jiang+2(1. Department of Toxicology, Guiyang Medical College, Guiyang 550004, China; 2. Department of Gastroenterology, 44th Hospital of PLA, Guiyang 550009, China);EXPRESSION AND SIGNIFICANCE OF PROLIFERATING CELL NUCLEAR ANTIGEN IN RESISTANCE OF LITHIUM CARBONATE TO AFLATOXIN B1-INDUCED HEPATOCARCINOGENESIS IN RATS[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-02
2 ZHANG Qiao-xin, LUO Wen-hong ,LI Hui, et al( The Center Laboratory of Shantou University Medical College,Shantou 515031,China);INVESTIGATION ON DNA DAMAGE OF HUMAN LYMPHOCYTES BY H_2O_2 WITH COMET ASSAY AND OBSERVATION OF THE COMET'S 3-D STRUCTURE BY CONFOCAL MICROSCOPE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-04
3 DONG Jie-ying 1 ,LOU Zhe-feng 1 ,ZHENG Zhong 2 ,et al (1.Department of Biology,Wenzhou Medical College,Wenzhou325035,China;2.Class of2000laboratory science,Wenzhou Medical College,Wenzhou325035,China);Use of the Single Cell Gel Electrophoresis/Comet Assay for Detecting the DNA Damage Effect of Formaldehyde to Mouse Testicular Cell in Vivo and in Vitro[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-03
4 HUANG Xiao-xin 1 ,ZHANG Ai-hua 2,ˇ ,HONG Feng 2 LU Shuang 2 ,CEN Du-cai 1 (1.44th Hospital of PLA,Guiyang550009,Guizhou,China; 2.School of Public Health,Guiyang Medical College, Guiyang550004,Guizhou,China);Expression of MDA and 4-HNE in AFB_1-Induced Rat Hepatic Putative Preneoplastic Lesions Alleviated by Li_2CO_3 and Their Significance[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-03
5 Zhang Aihua 1, Hong feng 1, Huang Xiaoxin 2 1 Department of Prevention Medicine, Guiyang Medical College, Guiyang\ 550004, 2 44th Hospital of PLA Guiyang 550009;EXPRESSION OF P 21 AND Bcl-2 PROTEIN IN AFB 1 INDUCED RAT HEPATIC PUTATIVE PRENEOPLASTIC LESIONS ALLEVIATED BY Li 2CO 3[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-04
6 Zhao Ying, Wang Zhi-qiang, Yang Zhi-ping, Wang Wei, Huang Xiao-mu (Anhui Center for Disease Control and Prevention ,Hefei,Anhui,230061,China);Initial Observation on DNA Trauma of Fish Red Blood Cell Caused by organic distill from Chaohu Lake[J];Anhui Journal of Preventive Medicine;2003-03
7 XU Jing-bo~1,YANG Li~1,ZHAO Li-qun~1,SUN Zhi-wei~2,SHI Long~2(1.Department of Environmental Science and Engineering,Northeast Normal University,Changchun 130024,China;2.College of Preventive Medicine,Jilin University,Changchun 130026,China);SCGE sduty on DNA damage of spermary cell in mice induced by m-nitrobenzene[J];Journal of Northeast Normal University (Natural Science Edition);2005-03
8 ZHANG Hong,HU Min,WU Han-wen.The Second Xiangya Hospital,Central South University,Changsha,410011,China$$$$;A Study on Metabolic Balance of Lithium in Normal Controls and Type-two Diabetes Mellitus[J];Journal of Chinese Physician;2001-07
9 Li Chaogan, Zhang Shuqiu, Nong song, et al (Department of Biochemistry, Youjiang Medical College for National Minorities, Baise, Guangxi 533000);The effects of Haierfu on blood biochemical indices in mice with arsenic poisoning[J];Chinese Journal of Control of Endemic Disenaces;2001-02
10 QIN Shu - yun, WEI Qi - hou, ZHANG Shu - qiu, et al ( Youjiang Medical College for Nationalities, Boise 533000, China);The effect of Haierfu Uquid on the prevention of arsenic on kidney in mice[J];Chinese Journal of Control of Endemic Disease;2003-03
China Proceedings of conference Full-text Database 2 Hits
1 LUO Peng,ZHANG Ai-hua,et al School of Public Health,Guiyang Medical College,Guiyang 550004,China);Influence of the Extract from Dictyophora Study on the liver lipid peroxidation caused by Arsenic in Mice[A];[C];2005
2 Yang Ping Li Aiping Liu Qizhan Zhou Jianwei (Department of Nutrition and Health , School of Public Health , Nanjing Meadical University);The Relationship between Lipid Peroxidation and Hormesis Caused by Sodium Arsenite[A];[C];2005
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 Huang Xiaoxin, Zhang Aihua, Luo Peng, Wu Yingkuan, Jiang Xianyao Chinese People's Liberation Army 44th Hospital, Guiyang 550009;EFFECTS OF ANTITUMOR AND TOXIC AND SIDE RESPONSE OF LITHIUM CARBONATE ON CYCLOPHOSPHAMIDE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1998-02
2 Zhang Aihua 1, Hong feng 1, Huang Xiaoxin 2 1 Department of Prevention Medicine, Guiyang Medical College, Guiyang\ 550004, 2 44th Hospital of PLA Guiyang 550009;EXPRESSION OF P 21 AND Bcl-2 PROTEIN IN AFB 1 INDUCED RAT HEPATIC PUTATIVE PRENEOPLASTIC LESIONS ALLEVIATED BY Li 2CO 3[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-04
3 TANG Hua-rong, HE Qun ① (Department of Blood Physiology, Xiangya School of Medicine, Central South University, Changsha 410078 ,China );Effects of lithium chloride on the proliferation and apoptosis of K562 leukemia cells[J];Bulletin of Hunan Medical University;2003-04
4 GUO Jian-wei, CAI Mei-ying, SHAO Bao-mei, et al. Department of immunology, West China university of medical sciences. Chengdu 610041;Detection of HSP70 expression on the membrane of human Hepatocellular carcinoma cell lines[J];Chinese Journal of Clinical Hepatology;2001-02
5 TAO Hui hong 1,LOU Jing ke 2,YANG Hu chuan 1,et al (1.Tumor Cytology Research Unit,Medical College of Shanghai Railway University Shanghai,200070 chiang 2.Taiyuan Railway Centre Hospital,Taiyuan 030013 China) \;;The experimental studies of inhibitory effects of lithium chloride in combination with hyperthermia on BGC 823 gastric cancer cell line[J];JOURNAL OF PRACTICAL ONCOLOGY;1999-04
6 Zhang Aihua;Zhang Qiao(Research unit of Genotoxicology,School of Public Health Sun Yat-sen Unit.of Medical Sciences,Guangzhou 510089);Studies on antimutagenic effect of lithium caroonate[J];JOURNAL OF HEALTH TOXICOLOGY;1995-01
7 PI Rong-Biao 1, QIU Peng-Xin 1, SU Xing-Wen 1, WAN Xiang 1, LI Ming-Tao 1, LIN Sui-Zhen 2, YAN Guang-Mei 1 (1. Department of Pharmacology, 2. Department of Pediatrics, the First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, Guangzhou;Protective effect of lithium on rat cerebellar granule neurons against apoptosis induced by LY 294002, a specific inhibitor of phosphatidylinositol 3-kinase in vitro[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;2000-03
8 Cai Dong-po and Wu Yi-yuan(Department of Immunology, Cancer Institute, Chinese Academy of Medical Sciences , Beijing 100021);THE ENHANCING EFFECT OF LITHIUM ON MOUSE LAK CELL ACTIVITY AND ITS ANTITUMOR ACTIVITY[J];CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY;1994-01
9 Wu Weizhong * Tang Xiaolei,Liu Kangda,et al.*Liver Cancer Institute,Zhongshan Hospital,Shanghai Medical University, Shanghai 200032;Induced expression of HSP70 on H22 cell and the prilimary study of the mechinasm of its anti tumor effects[J];CHINESE JOURNAL OF MICROBIOLOGY AND IMMUNOLOGY;1998-04
10 ;热休克蛋白70与IL-2抗肿瘤作用的对比研究[J];Chinese Journal of Oncology;2002-04
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 Zhang Zunzhen 1,Heng Zheng Chang 1,Li Nan 2,La Bazuoma 2 1 Department of Environmental Health, West China University of Medical Sciences, Chengdu 610041 2 Students of Preventive Medicine;STUDY ON THE DNA DAMAGE OF FIVE CHLORINATED ORGANIC COMPOUNDS IN V 79 CELLS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-01
2 Wang Lian-fang et al (Xinjiang Institute for Endemic Disease Control and Research, Urumqi);THE VALUE OF SKIN AFFECTIONS WITH KERATINIZATION IN PALMARIS ET PLANTARIS ETC. ON DIAGNOSIS OF CHRONIC ENDEMIC ARSENISM[J];Endemic Disease Bulletin;1987-01
3 $$$$ Yang Yiyong ,et al (Shanxi lnstitute for Endemic Disease Control and Research,Linfen 041000);A Study on Trace Elements and lntelligence of Children in IDD Eemic Area[J];ENDEMIC DISEASES BULLETIN (CHINA);1995-03
4 Meng Ziqiang Department of Environmental Sciences, Shanxi University, Taiyuan;RADIATION-INDUCED DNA SINGLE STRAND BREAKS AND THEIR REJOINING IN MAMMALIAN CELLS BY HYDROXYLAPATITE CHROMATOGRAPHY[J];Journal of Radiation Research and Radiation Processing;1987-04
5 Meng Ziqiang (Department of Environmental Sciences,Shanxi University,Taiyuan) Zhang Lianzheng (Institute for Radiation Protection,MNI);A METHOD FOR DETERMINATION OF STRAND SEPARATION RATE OF DNA IN ALKALI AND ITS USE INDNA DAMAGE STUDY[J];Acta Scientiae Circumstantiae;1988-01
6 Zhang Aihua;Zhang Qiao(Research unit of Genotoxicology,School of Public Health Sun Yat-sen Unit.of Medical Sciences,Guangzhou 510089);Studies on antimutagenic effect of lithium caroonate[J];JOURNAL OF HEALTH TOXICOLOGY;1995-01
7 Li Fu jun\ Sun Gui fan(School of Public Health,China Medical University,Shenyang\ 110001);The changes of certain Biochemical Function in heart of mice exposed to Sodium Arsenite in vitro and in vivo[J];JOURNAL OF HEALTH TOXICOLOGY;1998-03
8 Yang Yiyong;et al.(Institute of Provention and treatment of endemic diseases of Shanxi province,Linfen 041000,P.R.China);A STUDY ON THE DISTRIBUTION OF FLUORINE AND LITHIUM IN YUNCHENG.[J];MODERN PREVENTIVE MEDICINE;1995-04
9 Li Fujun,Sun Guifan,Dai Guojun,et alDepartment of Preventive Medicine,China Medical University,Shenyang 110001;Discussion of biomembrane injury mechnism in endemic arsenism patients[J];CHINESE JOURANL OF CNDEMIOLOGY;1998-01
10 Sun Guifan,Li Fujun,Li Gexin,Ding GuiyingDepartment of Preventive Medicine,China Medical University,Shenyang 110001;The exploration for the mechanism of arsenic on kidney toxicity in mice[J];CHINESE JOURANL OF CNDEMIOLOGY;1998-05
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