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IN VITRO ANTITUMOR EFFECTS OF PLEUROTAS SAPIDUS

SONG Xu-hong, ZHANG Yue-ming, DENG Hong(Department of Occupational Health, Xinjiang Medical University, Urumqi 830054, China)  
Purpose: To study the effect of the extract of Pleurotas sapidus on 4 tumor cell lines (human he-{patoma} cell Q-3, human gastric cancer cell MGC-803, human cervical carcinoma Hela cell, murine lung adenocarcinoma cell SPC-A-1). Methods: The survival cells and protein synthesis of tumor cell lines treated for 24 h with 10+{-1} g/ml~10+{-6} g/ml of the water and ethanol extracts from Pleurotas sapidus were determined by crystal violet staining and by Bradford assays. Results: ①There was a significant growth inhibition of tbe cell survival and protein synthesis of the cell lines at a dose of 10+{-1} g/ml of the water and ethanol extracts; ②The growth inhibition was found in different dose groups of ethanol extract. In the normal liver cells, the cell survival was not affected and the protein synthesis increased. Conclusion: The inhibition of the tumor cell lines with the extracts from Pleurotas Sapidus may be related to the inhibition of cell growth and protein synthesis.
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