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《Carcinogenesis,Teratogenesis and Mutagenesis》 2002-03
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ANTIMUTAGENIC EFFECT OF PROCYANIDINS FROM VITIS VINIFERA SEED IN SALMONELLA TEST

SUN Zhi guang\+1, ZHAO Wan zhou\+2, LU Yin\+2, TANG Ling fang\+3, ZHANG Zhen ling\+3, ZHANG Shi wei\+2 (1. Department of Digestion, Hospital of TCM of Jiangsu Province, Nanjing 210029; 2. College of Traditional Chinese Herbs, Nanjing University of T  
Purpose: Antimutagenic effect of procyanidins from Vitis vinifera seed was studied. Methods: A series of histidine requiring strains TA\-\{97\}, TA\-\{98\}, TA\-\{100\} and TA\-\{102\} were used for antimutagenicity test. Several mutagenic agents such as Sodium Azide(NaN\-3), Mitomycine C(MMC), Dexon, 2 AF, 1,8 Dihydroxyanthrachinon were used to make mutagenic model and antimutagenic effects of procyanidins were observed. Every tester strain was divided into model group, spontaneous mutation group and drug groups. Results: The results showed that procyanidins inhibited mutagenic effects induced by the most of the model agents, but little inhibitory effect was observed on TA\-\{102\} reverse mutation induced by 1,8 Dihydroxyanthrachinon(+S\-9). Conclusion: Antimutagenesis is one of mechanism chemoprevention of cancer of procyanidins.
【Fund】: 中国博士后科学基金资助项目 (No .1997)
【CateGory Index】: R285
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