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《Carcinogenesis,Teratogenesis and Mutagenesis》 2002-04
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EFFECTS OF MICROCYSTIC TOXINS IN DRINKING WATER ON CELL PROLIFERATION AND APOPTOSIS DURING THE COURSE OF HEPATOCARCINOGENESIS

CHEN Hua, SUN Chang sheng, HU Zhi jian, et al. (School of Public Htealth, Fujian Medical University, Fuzhou 350004, China)  
Purpose: To study the effects of drinking water contaminated with microcystins(MC) on cell prolife \{ration\} and apoptosis during the course of hepatocarcinogenesis,and to probe the mechanism of promoting hepatocarcinogenesis of microcystic toxins. Methods: 50 healthy Wistar rats were randomly divided into 4 groups: group A (normal control); group B (treated with DEN only); group C (treated with DEN and MC contaminated water); group D (treated with DEN and microcystins i.p ). The PCNA, Bcl 2 and Bax protein expression in preneoplastic liver tissue were detected using immunohistochemical assays. Results: The average integrated optical densities (AIOD) of PCNA in the experimental groups were 0.0033(group B), 0.0036 ( group C ) and \{0.0088\} (group D) respectively, and they were all significantly increased as compared to group A (0.0013). But as comparing to group B, only group D had significantly higher PCNA expression. Up regulation of Bcl 2 and down regulation of Bax expression were found in group C and group D. Conclusion: Uncontrolled cell proliferation caused by unbalanced expression of Bcl 2 and Bax gene may be one of the mechanisms of hepatocarcinoma promoted by microcystins.
【Fund】: 福建省科技项目 (项目号 :97Z176)
【CateGory Index】: R735.7
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