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《Carcinogenesis,Teratogenesis and Mutagenesis》 2002-04
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INHIBITION OF OSTHOL ON ADENOCARCINOMA AND SQUAMACARClNOMA OF LUNG

ZHOU Jun, CHENG We i xing, XU Yong hua, et al (Urumqi General Hospital of Lanzhou Command. PLA. Urumqi\ 830000, China)  
Purpose: To observed the inhibition effect of osthol on human lung adenocarcinoma and squamacarcinoma. Methods: Set up models of human lung adenocarcinoma and squamacarcinoma on the bodies of BALB/C, one kind of nude mice, then osthol was given to the mice in the dose of 1.5 μg/ (g·d) . Antitumor effect of osthol were valued by weighing the tumor and determing DR 70, the mark of lung cancer in BALB/C serum.Results: The inhibitory rates were 69.5 % on lung squamacarcinoma, and 50 % on lung adenocarcinoma, respectively also obviously decreased the level of serum DR 70. Conclusion: Osthol can inhibite the growing of lung adenocarcinoma and lung squamacarcinoma, especially the squamacarcinoma.
【CateGory Index】: R734.2
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