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《Carcinogenesis,Teratogenesis and Mutagenesis》 2003-01
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MUTAGENICITY RESEARCH OF No.Ⅱ DRUG

LIU Xiao_qiu, WANG Rong_xian, TIAN Qing_wei(Institute of Radiation Medicine Chinese Academy of Medical Sciences, Tianjin 300192 , China)  
Purpose and methods: The mutagenicity of No.Ⅱdrug was examined using Ames test, CHO_K cell chromosome aberration test and micronucleus test. Results: No.Ⅱ drug in the dose range of 1~5 000 μg / plate did not increase the number of reversion mutation in any of the 4 strains with or without S 9 in Ames test. The frequencies of micronuclear cell(MNCF) in PCE did not increase with dose of 25~125 mg / kg in micronucleus test. In CHO_K cell chromosome aberration test, the result was suspiciously positive because the frequency of chromosome aberration increased to 8 % with the dose of 250 μg / ml with S 9. Conclusion: The results of No.Ⅱ drug in Ames test and micronucleus test were negative, and at higher dose in chromosome aberration test the result was suspiciously positive.[
【Fund】: 天津市自然科学基金资助课题(No.103803811)
【CateGory Index】: R99
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