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《Carcinogenesis,Teratogenesis and Mutagenesis》 2003-01
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XU Yi_ping, SONG Rui_kun, SHI Nian, et al.(Department of Health Toxicology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030 , China)  
Purpose: To study the mutagenicity of Cultured Calculus Bovis. Methods: The studies were conducted with Ames test, micronuclei test and in vitro chromosome aberration test on human lymphocyte. Results: ① The results of Ames test showed no mutagenic effects with the concentration ranged from 1 250 μg / plate to 10 000 μg / plate. ② In micronuclei test, the mice orally received 50, 150, 500 mg / kg respectively per day for 2 days, no mutagenic effects were observed; and no significant reduction was observed on PCE / NCE ratio, compared with that of the negative control group(P0.05). ③ The in vitro chromosome aberration test on human lymphocyte showed a negative result with the sample concentration ranged from 1 μg / ml to 100 μg / ml. Conclusion: No mutagenicity was found with Cultured Calculus Bovis in this experimentation.[
【CateGory Index】: R99
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