Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Carcinogenesis,Teratogenesis and Mutagenesis》 2003-01
Add to Favorite Get Latest Update

EFFECTS OF CELL PROLIFERATION INHIBITION AND CHROMOSOME ABERRATIONS OF KUAISHALING AND DALTERMETHRIN ON MOUSE BONE MARROW

LI Xiao_yan 1, CHEN Xian_jun1, WANG Hui 2(1. Biology Department of Xianning Medical College. Xiannin 437100 ; 2. Pharmacology Department of Medical College, Wuhan University. Wuhan 430070 , China)  
Purpose: To detect the effects of cell proliferation inhibition and chromosome aberrations of Kuaishaling and Deltamethrin on mouse bone marrow. Methods:Two insectisides were administrated to mice at three different doses of 1 / 4, 1 / 2, 1×LD 50 (single doses of 1 / 20, 1 / 10 and 1 / 5×LD 50, the LD 50 of Kuaishaling and Deltamethrin were 72.8 mg / kg and 26 mg / kg) by gavage once a day for five days respectively, single gavaged volume was 20 ml / kg; the cell proliferation indices, the rates of chromosome structural aberrations and the rates of the cells with chromosome aberrations were detected by the methods of cytogenetics. Results: The cell proliferation indices of mouse bone marrow cells decreased significantly at all the three tested doses of these two insecticides as compared with the negative control group, the cell proliferation indices induced by Kuaishaling and Deltamethrin were 3.38±0.42~3.40±1.16 (P0.000 01) and 5.12±0.47~5.97±0.62 (P0.001~P0.000 1), respectively; both the rates of chromosomal structural aberrations and the rates of the cells with chromosomal aberrations increased significantly at the high dose of Kuaishaling and the three tested doses of Deltamethrin, the rates of chromosomal structural aberrations and the rates of the cells with chromosomal aberrations induced by the high dose of Kuaishaling were 8.87±1.65(P0.001) and 7.21±2.10(P0.01), respectively, those induced by the three tested doses of Deltamethrin were 11.74±2.81~23.42±2.17(P0.001~P0.000 1) and 9.36±1.52~17.33±3.68(P0.001~P0.000 1), respectively; the chromosomal aberration types caused by Deltamethrin were more complex than by Kuaishaling. Conclusions: Kuaishaling and Deltamethrin can not only inhibit cell proliferation, but also cause chromosome damages. Moreover, using LD 50 as the evaluating criterion, the effect of cell proliferation inhibition caused by Kuaishaling is stronger, whereas the effect of chromosome aberrations caused by Deltamethrin is stronger.[
【CateGory Index】: R99
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 3 Hits
1 ZHENG Wei-hua, ZHAO Jian-zhuang (Beijing Agricultural College, Beijing 102206);Development of Deltamethrin Toxicity and Mutagenicity[J];Journal of Beijing Agricultural College;2004-01
2 XU Guang-cui, YAN Xun,ZHANG Bo (College of Animal Science and Technology,Gansu Agricultural University,Gansu,Lanzhou 730070) College of Arts and Sciences,Beijing Union University,Beijing 100083,China);The damage of organophosphorous pesticide on male reproductive system[J];Journal of Gansu Agricultural University;2005-06
3 ZHAO Zhong-gui1,LI Peng2,LI Yu-bai1.1.Hunan environment biology institute 421001,China;2.Nanhua university life sciences institute 421001 Hunan hengyang,China;The Influence of insecticide (NongManYi) on The Rate of Micronucleus of Marrow Cell of Spraque dawley Rats.[J];Henan Journal of Preventive Medicine;2007-03
【Citations】
Chinese Journal Full-text Database 1 Hits
1 She Suzhen 1,Hu Daohua 2,Wang Jiaji 1,et al. 1Dept.of Health Toxicology,Anhui Medical University,Hefei 230032, 2Dept. of Health,Anqing Petrochemicol Works];A STUDY ON THE MUTAGENIC ACTIVITY IN DRINKING WATER ORGANIC EXTRACT IN ANQIN[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1996-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 Chen Xianjun, Zhao Honggang Biology Department and Pathology Department, Xianning Medical College, Hubei 437100;HIGH DOSE SELENTUM INDUCED SCE AND CHROMOSOME ABERRATION IN HUMAN LYPHOCYTES[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-02
2 MEI Shu-jiang,LIU Ya,WANG Bao- Gui,et al(1.Department of biiology,Shantou University Medical College,Shantou 51503 1,China;2.College o f Preventive Medicine,Jilin University,Changchun 130021, China;3.Health Supervision Office of Changchun Health Bureau Changchun 130021,China);STUDY ON ACUTE TOXICITY AND MUTAGENTICITY OF POLYOXOANIONS α-K_8H_2[SiW_9Ti_3O_40]·15H_2O[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-03
3 ZHU Wei-yun, PANG Zhu-lin, LIANG Min-yi, et al(Department of Medical Genetics and Cell Biology, Guangzhou Medical College, Guangzhou 510182,China);THE EFFECT OF TARAXACUM MONGO TO INHIBIT THE MUTATION IN THE BONE MARROW LYMPHOCYTE OF MICE INDUCED BY CYCLOPHOSPHAMIDE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-03
4 YU Miao et al(College of Life Science,Henan Normal University,Xinxiang,Henan 453007);Experiment on Acute Toxicity of Ionic Liquid 1-octyl-3-methylimidazolium Bromide to Mice[J];Journal of Anhui Agricultural Sciences;2008-09
5 ZHENG Wei-Hua~1, ZHAO Jian-Zhuang~1,MA De-Ying~2,HOU Shi-Cong~3(~1Beijing Agricultural College, Beijing 102206;~2Xinjiang Agricultural University, Xinjiang,830052;~3China Agricultural University ,Beijing 100094);Development of Determination of Deltamethrin[J];Journal of Beijing Agricultural College;2003-04
6 LI Hong-tao,ZHOU Wen-zong,GAO Hong-li,ZHANG Luo(Institute of Geography,The Henan Academy of Sciences,Zhengzhou 450052,China);Joint Toxicity of Salinity and Alkalinity to Oriential Weatherfish Misgurnus anguillicaudatus by Uniform Design[J];Fisheries Science;2006-11
7 YANG Zhi-gang,ZHANG Yan-ping (Dept.of Bio.Changshu College,Changshu 215500,China);Effects of Hg~(2+)、Cd~(2+) ions on physiological indications of Garlic[J];Journal of Changshu College;2004-02
8 WANG Yi-yun,WANG Chang-hai(Dept.of Biosci.and Biotechnol.,Dalian Univ.of Technol.,Dalian 116024,China);Study of selectable markers in genetic engineering of Chlorella sp.[J];Journal of Dalian University of Technology;2007-04
9 CUI Li-li,ZHAO Yun-long,XUN Xiao-qian,QIN Fen (School of Life Science,East China Normal University,Shanghai 200062,China);Effects of Water-borne Copper on Accumulation,Distribution of Copper and Digestive Enzymes Activities in Sesarma dehaani[J];Journal of Fudan University(Natural Science);2007-06
10 LIU Zhi-bin, ZHANG Yue-jin, WANG Juan (College of Resource and Environment Engineering, Liaoning Technical University, Fuxin 123000, China);Research of influence of leaching water of gangue on environments[J];Journal of Liaoning Technical University;2005-02
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 GENG De gui, QU Ai, WANG Jing ming, CHEN Gang, LI Zong yun (Department of Biology, Xuzhou Normal University, Xuzhou 221009, China);GENETIC TOXICITY IN CELLS OF MONOPTERUS ALBUS EXPOSED BY THE HERBICIDE JING KE CAO XING[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;2000-01
2 Zheng Lukang, Deng Lixia, Zhang qiao Lab. of Genetic Toxicology, School of Public Health, Sun Yat Sen University of Medical Sciences, Guangzhou 510089;STUDY ON THE ANEUPLOIDY FREQUENCY IN HUMAN SPERM CHROMOSOME USING FLUORESCENCE IN SITU HYBRIDIZATION (FISH)[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1998-05
3 Huang Dezhi et al (Teaching Affairs Office, Anhui Agricultural University, Hefei 230036);Research Progress of Analysis of Pesticide Residue[J];Journal of Anhui Agricultural Sciences;2002-04
4 YIN Xiao-hui 1,2, ZHAO Zhen-yu2, JIANG Hu3, LIN Rong-hua3, GAO Xi-wu1(1Department of Entomology, China Agricultural University, Beijing 100094, China; 2 Department of Agricultural, Xinjiang Agricultural University, Urmqi 830000,China; 3 Institute for the control of Agrochemicals, Ministry of Agriculture, Beijing 100026, China );Effects of deltamethrin on specific activities and tissue distribution of glutathione S-transferase in Pseudorasbora parva[J];Journal of Safety and Environment;2005-04
5 XU Xiao-Ping, XI Yi-Long **, CHU Zhao-Xia, CHEN FangCollege of Life Science,Anhui Normal University,Provincial Laboratory of Conservation and Utilization for Important Biological Resource in Anhui, Wuhu 214000, China;Effect of deltamethrin on experimental population dynamics of freshwater rotifers Brachionus calyciflorus[J];Acta Zoologica Sinica;2005-02
6 LI Yanxia\ YANG Jianmei (College of Life Science, Peking University, Beijing, 100871);Comparison of the Toxicity and the Influence of Enzyme Activity of Four Kinds of Insecticides to Daphnia magna[J];ACTA SCICENTIARUM NATURALUM UNIVERSITIS PEKINESIS;1997-02
7 Chang Bo;Li Guangming;Tang Baiji;et al.(Shanghai Municipal Corps Hospital, Chinese People's Armed Police Forces,Shanghai 201103);Changes of Superoxide Dismutase, Lipid Peroxide and Glutathione Peroxidase in Acutc Organophosphorus Insecticide Poisoning[J];LABELED IMMUNOASSAYS AND CLINICAL MEDICINE;1996-01
8 YANG Hailing,NIE Lijia,ZHU Shenggeng,ZHOU Xianwan(College of Life Sciences,Peking University,Beijing 100871,China);Structure and Catalytic Mechanism of the Glutathione Transferases[J];Journal of Chengdu University(Natural Science Edition);2006-01
9 GAO Yong chuang 1, WANG Shu min 1, GUO Zhen qun 2, LIU An xi 2 (1 Department of Biology, Langfang Teachers College, Langfang 065000,China; 2 Department of Biology, Nankai University, Tianjin 300071,China);Inhibition of deltamethrin and phoxim mixtures on the sodium channels of neuron cell[J];Journal of Agricultural University of Hebei;2002-03
10 Liu Junting; Fan Chuichang(Department of Forensic Chemistry, China Medical University,Shenyang 110001);EXPERIMENTAL SYUDY ON ISOLATION AND CLEAN-UP SYNTHETIC PYRETHROID INSECTICIDES FROM BIOLOGICAL SAMPLES WITH SOLID PHASE EXTRACTION[J];Chinese Journal of Forensic Medicine;1996-02
【Secondary References】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Jinga,WANG Chun-na b,WEI Chao-junb,ZHAO Jian-zhuangb,SHI Ya-juna (a.Department of Plant Science and Technolog,b.Department of Basic Sciences,Beijing University of Agriculture,Beijing 102206,China);Development of ELISA Kit for Deltamethrin Residue[J];Journal of Beijing University of Agriculture;2009-02
2 ZHAO Hua-Qiang1 WANG Dong1 LI Bing1,2 XU Ya-Xiang1,2GONG Cheng-Liang1,2 SHEN Wei-De1,2*(1College of Life Sciences,Soochow University,Suzhou Jiangsu 215123,China;2Institute of Sericulture,Soochow University,Suzhou Jiangsu 215123,China);Comparison of Toxicities of Pesticide Deltamethrin to Bombyx mori and Bombyx mandarina[J];Science of Sericulture;2008-01
3 CHEN Shu-bing*,YU Xue-jun,FAN Yuan-mu,HE Xiao-yu,XIE Dong-hua and LI Zuo-qing(Food Safety Testing Subsection,Inspection and Quarantine Technology Center,Ningbo Entry-exit Inspection and Quarantine Bureau of the People′s Republic of China,Ningbo 315012);Rapid determination of endosulfan,endosulfan-sulfate and deltamethrin residues in aquatic products by free-zing-lipid filtration,solid-phase extraction and gas chromatography[J];Chinese Journal of Analysis Laboratory;2008-04
4 ;Relative Study on Deltamelthrin Exposure and Mortality Due to Digestive System Sarcomata[J];Environmental Protection Science;2005-04
5 TANG Li-bo, LIU Yan. Zhuhai Campus,Zunyi Medical College,Zhuhai,Guangdong 519043,China;Effect of Pesticides on Sister-Chromatid Exchange and Micronuclei Frequency of Garlic Root Tip Cells[J];Journal of Environment and Health;2009-04
6 ZHOU Ming-ying1,SUN Yao1,LIU Xia2,QIAO Xiang-ying1(1.Yellow Sea Fisheries Research Institute,Chinese Academy of Fishery Sciences,Key Laboratory for Sustainable Utilization of Marine Fisheries Resources,Ministry of Griculture,Qingdao 266071,China;2.College of Chemistry and Chemical Engineering,Ocean University of China,Qingdao 266003,China);Study on method of determination of deltamethrin in sediment from cultivating area[J];Marine Environmental Science;2009-01
7 ZHANG Zhi-yong,YU Xiang-yang,WANG Dong-lan,LIU Xian-jin(Institute of Food Safety Research & Inspection,Jiangsu Academy of Agricultural Sciences,Nanjing 210014,China);Determination of Pyrethroid Insecticides Residues in Water and Soil[J];Jiangsu Journal of Agricultural Sciences;2009-02
8 ZHANG Jing, WEI Chao-jun, WANG Chun-na, WANG Jing, ZHAO Jian-zhuang (Beijing University of Agriculture, Beijing 102206, China);Development of Enzyme Immunoassays for Deltamethrin[J];Journal of Agro-Environment Science;2009-05
9 WU Jia-lun~*,ZOU Yao-hua,LI Li-qing (Institute of Pesticide and Environmental Toxicology,Zhejiang University,Hangzhou 310029,China);Multi-residue Analysis of Fifteen Organochlorine and Pyrethroid Insecticides in Raidix paeoniae Alba and Rhizoma coptidis[J];Chinese Journal of Pesticide Science;2006-01
10 ZOU Xin-zhuo,ZHENG Zu-biao(Department of Chemistry,East China Normal University,Shanghai 200062,China);Study on Bioactivity of α-Cyano-4-Fluoro-3-Phenoxybenzyl Ester of Monochlorinated Pyrethric Acid[J];Modern Agrochemicals;2009-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved