STUDY ON ANTIMUTAGENICITY OF CHINESE HERBAL MEDICINE AND GREEN TEA TO BENZOAPYRENE AND NNK
ZHANG Chun_ling, HU Jun_feng, QU Jiang_bin, et al.(School of Public Health, Shandong University, Jinan 250012 , Ch ina)
Purpose: To investigate the antimutagenicity of water extract of green tea, tea polyphenol, Scutellaria barbata D. Don, Hedyotis diffusa wildi and Xihuangwan to benzoapyrene and 4_methylnitrosamino_1_(3_pyridy)_1_butanone(NNK). Methods: The A mes test was used in this study. Results: Except the lowest dosage group, all the other dosage groups of green tea, te a polyphenol, Scutellaria barbate,Hedyotis diffusa wildi and Xihua ngwan inhibited the reverse mutation of TA 98 and TA 100 induc ed by B(a)P and NNK significantly(P0.01). Conclusion: The teste d Chinese herbal medicines and green tea have antimutagenicity to B(a)P and NNK, and there is a dose_effect relationship.