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《Carcinogenesis,Teratogenesis and Mutagenesis》 2003-03
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THE EFFECT OF TARAXACUM MONGO TO INHIBIT THE MUTATION IN THE BONE MARROW LYMPHOCYTE OF MICE INDUCED BY CYCLOPHOSPHAMIDE

ZHU Wei-yun, PANG Zhu-lin, LIANG Min-yi, et al(Department of Medical Genetics and Cell Biology, Guangzhou Medical College, Guangzhou 510182,China)  
Purpose: To study the effects of Taraxacum mongo(T M) on anti-mutation and cell proliferation. Methods: Mitotic Inde x(MI), chromosome aberration and micronucleus test in bone marrow lymphocytes of mice were determined. Results: ①The MI of bone marrow lymphocytes in mice were in hibited by CP(P 0.01),but MI were significantly increased compared with contr ol group after TM oral feeding on mice (P 0.01). ②The in hibition rates of chromosome aberration were 39.62 %, 58.49 % and 54.72 % ,respectively by TM in different concentrations of low, medium and high, furthermore the frequencies of micronucleu s(MN) were inhibited by CP(P 0.05). Conclusion: No mutagenici ty was observed on TM .but TM possesses the ability of anti _ mutation,and promotes cell proliferation.
【CateGory Index】: R285
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