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《Carcinogenesis,Teratogenesis and Mutagenesis》 2003-04
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STUDY OF TER ATOGENICITY OF PIOGILISTAZONE HYDROCHLORIDA IN RATS

LIAO Xue1, WANG Jie1, SONG Hong-yu1, et al(1.National Research Center for New Drug Safety Evaluation ,Shenyang 110021,China;2.The Ninth Hospital of Shenyang, shenyang 110024,China)  
Purpose: This study was undertaken to determine the potentially teratogenic effects of pioglitazone hydrochloride to Wistar rats. Methods: The study was conducted with three groups orally administered with 6, 24, and 96 mg/kg doses continuously for 10 days from 6th to 15th day after gestation of rats. Positive (2 mg/kg Dikushuang) and negative controls (0.5 % CMCNa) were performed at the same time with the method. Results: the number of absorptive embryo and dead fetus increased in the high dose group (96 mg/kg). The stunt effect of pioglitazone hydrochloride to the fetus was observed in all dose groups. Conclusion: Pioglitazone hydrochloride showed obvious embryo toxicity, but no teratogenic effect to fetus was observed.
【CateGory Index】: R96
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