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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-01
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Study of Anti-tumor and Mechanism of Organogermanium Poly-derivatinmves

ZHANG Yu, WANG Bao - gui, ZHANG Gui - ying, et al ( 1. College of Preventive Medicine, Jilin University, Changchun 130021, China; 2. Leader Ward of The First Hospital, Jilin University , Changchun 130021, China)  
BACKGROUND AIM: To study the cytotoxicity on normal cell , the inhibitive effect of Organogermanium Poly - derivatimves on cancer cell and the effect on cell cycle in vitro, and provide a basis to clinical usage. MATERIAL AND METHODS: The cytotoxicity on FL, L929 and the inhibitive rate of Organogermanium Poly - derivatimves on SMMC - 7721, Hela, K562 in vitro were onducted with the method of MTT; The effect of Organogermanium Poly - derivatimves on cell cycle was studied by the way of One - Fluorescence Dying with Flow Cytometer. RESULTS: ①When the dosage reached 160.00 μg/ml, Organogermanium Poly - derivatimves did not show any cytotoxicity on FL and L929, and even stimulated cell growth; When the dosage was 160.00-1280.00 μg/ml, bigger dose showed higher cytotoxicity. ② In vitro, the inhibitive rate curve of Organogermanium Poly - derivatimves on SMMC - 7721, Hela, K562 were all two - peak curve. When the dosage reached 2.50 μg/ml,the first peak of the curve, the inhibitive rate of Organogermanium Poly - derivatimves on SMMC - 7721, K562 were 12.6 % , 32.8 % respectively, and on Hela, When the dosage reached 5.00 μg/ml, inhibitive rate was 10.6 %, and decreased with higher dose. When the dosage was 80.00-1280.00 μg/ml, the inhibitive rate rised with higher dose. When the dosage reached 1 280.00 μg/ml, the inhibitive rates were 66.0 %,59.9 %,65.8 % respectively. ③When the dasage reached 5.00 μg/ml, 320.00 μg/ml, after 48 hours, Organogermanium Poly - deriva-timves could extend G0/G1 and shorten S, G2 of cell cycle on SMMC - 7721. CONCLUSION: At micro - dose, Organogermanium Poly - derivatimves showed obviously inhibiton to SMMC - 7721, Hela, K562 and effect to cell cycle on SMMC - 7221,have also observed.
【CateGory Index】: R73-36
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