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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-01
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Anti-mutagenicity test of PS8812 Polysaccharides and its Selenium Polysaccharides

ZHANG Quan-xin, NIE Mu-hai (Department of Toxicology, Guangzhou Center for Diseases Prevention and control, Guangzhou 510080, China)  
BACKGROUND AIM:To study the antimutagenic effect of PS8812 Polysaccharides (PSP) and its Selenium Polysaccharides(PSSP) .MATERIAL AND METHODS: The Ames test, mouse marrow micronueleus test and mouse sperm malformation test were used. RESULTS: PSP and PSSP both could evidently inhibit the reverse mutation on Salmonella thphimurium strains TA98 and TA100 with and without S9 mix. The rates of maximum inhibition were 65.39 % and 73.21 % respectively. The frequencies of micronueleus and abnormal sperms induced by cyclophosphamide (CP)were reduced significantly by PSP and PSSP. The inhibitory rate of micronueleus was between 40.24% and 60. 37%; the inhibitory rate of abnormal sperms was between 38.92 % and 62.36 % .CONCLUSION: PSP and PSSP have significant antimutagenic effect.
【CateGory Index】: R96
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