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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-03
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The Effect of Trivalent Chromium and Hexavalent Chromium on the Micronuclear Rate and the Sperm Abnormality of Mice

KAO Qing-jun,WU Kun ,LI Hong-wei,et al (1.Public Health college,Harbin Medical University,Harbin150001,China;2.The aquatic products institut of Heilongjiang province,Harbin150001,China)  
BACKGROUNDAIM: To evaluate the toxic effect of chromium to the boby cell and the sperm of mice. MATERIAL AND METHODS: The micronuclear test in polychromatic erythrocytes(PCES)of bone marrow and the sperm abnormality test were applyed in mice model. RESULTS: For the micronuclear test,use1/5LD 50 、1/10LD 50 、1/20LD 50 as the high,middle,and low dosage respectively.The results showed that CrCl 3 had no significant effect on the micronuclear rate in treatment groups and control group(P0.05).While K 2 Cr 2 O 7 could dramatically increase the micronuclear rate,which was significantly higher than that of control group(P0.01).the ratio of PCE/RBC in every group presented in reverse relationship with the dosage of CrCl 3 and K 2 Cr 2 O 7 ,but higher than0.1.For the sperm abnormality test,use1/2LD 50 、1/4LD 50 、1/8LD 50 as the high,middle,and low dosage respectively.The sperm abnormality rate of CrCl 3 and K 2 Cr 2 O 7 treatment groups were significantly higher than that of control group(P0.05). CONCLUSION: CrCl 3 have no toxicity on the boby cell and might have genotoxicity effect on the sperm of mice.K 2 Cr 2 O 7 has significantly toxicity on the boby cell and sperm of mice.With the same dosage of lethal effect,the toxicity effect of K 2 Cr 2 O 7 is significantly stronger than that of CrCl 3 .
【Fund】: 农业部农业行业标准项目(No.03184)
【CateGory Index】: R114
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