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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-04
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Effects of Holmium Element on DNA Lesion of Mice Liver Cells in Vivo

WANG Cheng_run 1 ,MIN Li 2 ,WU Wei 3 ,et al (1.Department of Chemistry and Biology,Huainan Normal College,Huainan232001,China;2.Library,Huainan Normal College,Huainan2320001,China;3.Biological Engineering Center,Xuzhou Normal University,Xuzhou221116,China)  
BACKGROUNDAIM: To study the effect of holmium ions on DNA breakage of mice liver cells and the effect of holmium element on apoptosis of zoic cells in vivo. MATERIAL AND METHODS: Group1:Mice were adˉministered orally with daily dose of50mg/kg of holmium chloride solution for5days;Group2~3:Mice were treated intraperitoneally with daily dose of60mg/kg and120mg/kg of holmium chloride solution twice respec tively.Group4:Mice were treated intraperitoneally with a single dose of320mg/kg of holmium chloride solution.In group1~3,the interval of poisoning was24h,and DNA was extracted from mice livers24h after the last poisoning in groups above.Group5:Mice were administered intraperitoneally with the same volume of saline as below.Group6~9:Mice were treated intraperitoneally with a single dose of80mg/kg of holmium chloride soˉlution and DNA was extracted at12,24,48and96h respectively.Agarose gel electrophoresis was performed to observe the tapes'change. RESULTS: In group7,a continual diffusive tailed tape was showed,but no obvious DNA_tailed tape observed in all the other groups.Meanwhile,no DNA ladder was found,too. CONCLUSIONS: It is possible that the extension of DNA breakage caused by holmium ions to mice liver cells was associated with dose,treating duration and DNA_repair,which had no specificity.The results suggest that holmium element couldn't induce apoptosis of mice liver cells in vivo in the experiments.
【Fund】: 淮南师范学院引进人才专项基金项目(No.03K060518)
【CateGory Index】: Q25
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