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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-05
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Study about Anti-tumor Effect of Rhizoma Menispermi Extracts in Vitro

SHAN Bao-en 1 ,LIANG Wen-jie 1 ,REN Feng-zhi 2 ,et al (Research Center,The Fourth Hospital of Hebei Medical University,Shijiazhuang050011,China;2.NCPC New Drug R&D co.Ltd,Shijiazhuang050015,China)  
BACKGROUNDAIM: To study the antitumor effect of Rhizoma Menispermi extracts and purify its'active component. MATRAIAL AND METHODS: The effect of Rhizoma Menispermi extracts on the proliferation of12kinds of tumor cell lines and9cases of tumor cell coming from patients were assayed in vitro using MTT colorimetric method.The antitumor active part of Rhizoma Menispermi extracts was separated and purified using three steps method. RESULTS: Rhizoma Menispermi extracts markedly inhibits the proliferation of12kinds of tumor cell lines,and with a dose-dependent relationship(P0.01).Rhizoma Menispermi extracts also inhibits the proliferation of9cases of tumor cell coming from patients by primary culture.The antitumor active part was found. CONCLUSION: Both Rhizoma Menispermi extracts by water(RMW)and Rhizoma Menispermi extracts by ethanol(RME)have very strong antitumor effent in vitro;The effect of RME is stronger than RMW;PE2is the antitumor active part of RME;PE2not only has very strong and extensive inhibitive effect on the tumor cell lines but also has inhibitive effect on the tumor cell coming from patients by primary culture.It need the further development as antitumor drug.
【CateGory Index】: R73-36
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