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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-05
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Examination of the Mutagenetic Effect of the Recombinant Staphylokinase

LIU Yong-xue,WANG Qiong,GAO Pei-yong (Department of Pharmacology and Toxicology,Beijing Institute of Radiation Medicine,Beijing100850,China)  
BACKGROUNDAIM: To investigate if the recombinant staphylokinase has the effect of mutagenesis. MAˉTERIAL AND METHODS: Ames test,chromosomal aberration test in CHL cell and micronucleus test in mouse bone marrow were carried out. RESULTS: The recombinant staphylokinase at0.7~40mg/plate induced neither remarkable nor dose-dependent reverse mutagenecity to four auxotrophic mutants TA 97 ,TA 98 ,TA 100 and TA 102 with or without S 9 mix.Concentrations between1.25and5mg/ml induced neither a dose-dependent nor significant increase in number of structural and numerical chromosomal aberrations with or without S 9 mix.At24h after administration,the freˉquencies of micronucleated polychromatic erythrocytes in bone marrow of mice treated with recombinant staphylokinase between125and500mg/kg did not increase compared with the control mice. CONCLUSION: The recombinant staphylokinase has no effect of mutagenesis.
【CateGory Index】: R96
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【Citations】
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【Co-citations】
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1 LIANG Hai-ying, ZHANG Xiao yuan, LIANG Song ping (Laboratory of Protein Chemistry, College of Life sciences, Hunan Normal University, Changsha 410081, China);THE STUDY ON MUTAGENICITY OF HUWEN ANALGESIC PEPTIDE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-03
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5 YU Yan 1 ,LIN Fei 2 ,ZHANG Rui-juan 1 ZHANG Zhen-jun 1 ,LI An-jing 1 (1.College of Medical Science,Xi'an Jiaotong University,Xi'an 710061,Shanxi China;2.Assessment Institute of Drugs and Biology Products of China,Beijing100050,China);The Toxicity Study of Recombinant Human Glucagon-like Peptide on Rats During the Period of Sensitive Teratogenesis[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-03
6 LIN Fei 1 ,LU Lian 1 ,YANG Xu-qing 2 ,CUI Wei-chuan 2 ,WANG Feng-min 2 (1.National Institute for the Control of Pharmaceutical and Biological Products,Beijing100050,China;2.The Science System Corporation of Beijing Xingda,Beijing100081,China);The Comparison Study of Major Target Organ Hurt Induced by Dicycloplatin and Its Derivates in Rats[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-05
7 PAN Jing-yuan,QIU Yin-sheng,YAN Han-chi,LING Sa (Center of Pharmacology and Toxicology,Hubei Pharmaceutical Industry Research Institute,Wuhan430061,Hubei,China);Study on the Teratogenicity of Erythromycin Propionate-N-Acetylcysteinate in Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-01
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