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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-06
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Effects of Coal Tar Pitch on DNA Damage in Peripheral Blood Lymphocyte in Occupationally Exposed Workers

ZHANG Qiao, ZHOU Fang, LI Shi-en, et al (Department of Occupation Health, School of Public Health, Zhengzhou University, Zhengzhou 450052, China)  
BACKGROUND AIM: To study the adverse effect of coal tar pitch (CTP) on DNA damage of peripheral blood lymphocyte in occupationally exposed workers. MATERIAL AND METHODS: Micronucleus (MN) and single cell gel electrophoresis(SCGE) were used to determine DNA damage of peripheral blood lymphocyte in 43 workers exposed CTP and 21 controls. RESULTS: The frequencies of comet-like tail and MN of peripheral blood lymphocytes were(3.26 ± 1.12) × 10 -2 and (1.23 ±0.27) × 10 -3 , significantly higher in CTP-exposed group than those in control group (P 0.01; P0.01), and these effects could increase with the extension of time exposed CTP(P 0.01; P0.05) . CONCLUTION: Exposing to CTP for a long-term may induce DNA damage in peripheral blood lymphocyte in workers, and thus SCGE and MN may be used as early monitoring markers for high-risk individual of occupational lung cacer.
【CateGory Index】: R131
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