Study on the Acute Toxicity and the Genetic Damage of Chromosome in Mice After Exposure to Hydroxylammonium Nitrate
JIA Qing-jun, YANG Lu-jun, LIU Jin-yi, et al (Department of Hygienic Toxicology, Preventive Medicine College, Third Millitary Medical University, Chongqing 400038, China)
BACKGROUND AIM: To explore the acute toxicity and LD50, and study the genetic damage of bone marrow cells induced by Hydroxylammonium Nitrate. MATERIAL AND METHODS: After celiac administration of HAN in mice, the mortality and the physiological changes were observed; Chromosome aberration test, micronucleus test in mouse were used. RESULTS: The LD50 of HAN in male on 24 hour and 14 day was 186 mg/kg(185-187 mg/kg) and 183 mg/kg (182- 184 mg/kg), respectively. No pathological change of the organs was found. There were significant findings in chromosome aberration and micronucleis rates in experimental groups compared with those of the negative control group(P 0.05). CONCLUSION: According to the standard of grading of acute toxicity,HAN belongs to the moderate class. The genetic damage of bone marrow cells can be induced by Hydroxylammonium Nitrate.