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《Carcinogenesis,Teratogenesis and Mutagenesis》 2004-06
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Effect on Testicular Germ Cell and Sperm in Mouse After Exposure to Hydroxylammonium Nitrate

JIA Qing-jun, YANG Lu-jun, LIU Jin-yi, et al (Department of Hygienic Toxicology, Preventive Medicine College, Third Millitary Medical University, Chongqing 400038, China)  
BACKGROUND AIM: To study the reproductive damage of testicular germ cell and the deformity of sperm in mouse induced by Hydroxylammonium Nitrate (HAN) . MATERIAL AND METHODS: Testicular germ cell micronucleus test, sperm deformity assay and flow cytometry were used. RESULTS: It showed that the percentage of deformity in sperm was markedly increaed as the dose increased(P 0.05), the percentage of micronucleus was significately decreased as the dose increased (P 0.05) . The toxic effect of sperm was correlated with exposuring HAN . CONCLUSION: It suggested that HAN might have reproductive damage effect to testicular germ cell and sperm in mice.