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Embryotoxicity and Teratogenicity of Han in Mice

JIA Qing-jun, ZHOU Yan-hong, LIU Jin-yi, et al (Department of Hygienic Toxicology, Preventive Medicine College, Third Millitary Medical University, Chongqing 400038, China)  
BACKGROUND AIM: To study the embryotoxicity, the teratogenic effect of Hydroxylammonium Nitrate (HAN) and its teratogenic characteristics. MATERIAL AND METHODS: The body weight,the death rate of fetuses and the rate of absorbed embryos were counted. The External appearances and internal organ and the skeleton of the mouse embyos were observed . RESULTS:After the mice were given different doses of HAN,their weight, the number of living embryo, the number of absorbed embryo and the number of dead embryo did not change obviously. The weight of the embryo did not changed apparently. The abnormality in statistics was not found in the skeleton of the mouseembryos, the exterior and the internal organs. CONCLUSION: HAN has no malformed effect on the mouse embryos.
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