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《Carcinogenesis,Teratogenesis and Mutagenesis》 2005-02
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Genetic Polymorphism in hOGG1 and Susceptibility to Lung Cancer

WANG Wei 1,2 ,WU Yong-jun 1 ,WU Yi-ming 1,ˇ (1.Department of Occupational Health and Health Toxicology,College of Public Health,Zhengzhou University,Henan Zhengzhou450052, China;2.Zhengzhou Institute of Occupational Disease, Zhengzhou Henan450053,China)  
BACKGROUNDAIM: To examine the association between Ser326Cys polymorphism in hOGG1gene,which is involved in the repair of8-hydroxyguanine in damaged DNA,and investigate the risk of lung cancer in Chinese. MATERIAL AND METHODS: Ser326Cys polymorphism in hOGG1gene was determined by PCR-RFLP among128normal controls and124patients with lung cancer.The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis. RESULTS: The Cys/Cys genotype of hOGG1was found in19.4%of patients with lung cancer and in10.2%of the controls(P0.05).Homozygosity for the Cys/Cys genotype significantly increased the risk of developing cancer,with the odds ratio adjusted for age,sex and smoking being2.12(95%CI=1.03~4.39). CONCLUSION: Polymorphism of hOGG1Ser326Cys may play a role in lung carcinogenesis.
【Fund】: “211工程”重点学科研究项目资助
【CateGory Index】: R734.2
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