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《Carcinogenesis,Teratogenesis and Mutagenesis》 2005-02
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Genetic Polymorphism in hOGG1 and Susceptibility to Lung Cancer

WANG Wei 1,2 ,WU Yong-jun 1 ,WU Yi-ming 1,ˇ (1.Department of Occupational Health and Health Toxicology,College of Public Health,Zhengzhou University,Henan Zhengzhou450052, China;2.Zhengzhou Institute of Occupational Disease, Zhengzhou Henan450053,China)  
BACKGROUNDAIM: To examine the association between Ser326Cys polymorphism in hOGG1gene,which is involved in the repair of8-hydroxyguanine in damaged DNA,and investigate the risk of lung cancer in Chinese. MATERIAL AND METHODS: Ser326Cys polymorphism in hOGG1gene was determined by PCR-RFLP among128normal controls and124patients with lung cancer.The association between this genetic polymorphism and the risk of the cancer was examined by a multivariate analysis. RESULTS: The Cys/Cys genotype of hOGG1was found in19.4%of patients with lung cancer and in10.2%of the controls(P0.05).Homozygosity for the Cys/Cys genotype significantly increased the risk of developing cancer,with the odds ratio adjusted for age,sex and smoking being2.12(95%CI=1.03~4.39). CONCLUSION: Polymorphism of hOGG1Ser326Cys may play a role in lung carcinogenesis.
【Fund】: “211工程”重点学科研究项目资助
【CateGory Index】: R734.2
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【References】
Chinese Journal Full-text Database 4 Hits
1 FU Gang SHEN Xiao-bing~* (School of Public Health,Southeast University,Nanjing 210009,China);Advances in the Relationship of DNA Repair Genetic Polymorphism and Gastric Cancer Susceptibility[J];Journal of Environmental & Occupational Medicine;2007-06
2 YANG Yuan, HU Changjun, TIAN He, HE Sheng Department of Clinical Laboratory, Huaihua Medical College, Huaihua 418000, China;Association of Human 8-Oxoguanine Glycosylase 1 Polymorphism with the Susceptibility of Laryngeal Cancer[J];Tianjin Medical Journal;2008-08
3 JI Long,ZENG Xiaoyun,LI Longman,QIU Xiaoqiang,CHEN Sixia,YU Hongping School of Public Health,Taishan Medical Colloge,Tai'an 271000,China;Interaction between the single-nucleotide polymorphism of DNA repair gene hOGG1 and HBV infection and its susceptibility to hepatocellular carcinoma[J];Journal of Hygiene Research;2011-06
4 DU Guobo TAN Bangxian LIU Mi MA Daiyuan SHU Xiaohong Department of Oncology,First Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Research of relationship between genetic polymorphism of hOGG1 gene and susceptibility to lung cancer in the population of northern Sichuan of China[J];China Modern Medicine;2012-33
【Citations】
Chinese Journal Full-text Database 1 Hits
1 MENG Zi qiang\+1, ZHANG Lian zhen\+2 (1. Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006,China; 2. China Institute for Radiation Protection, Taiyuan 030006, China);DNA OXIDANT DAMAGE INDUCED BY TOBACCO SMOKE IN HUMAN BLOOD LYMPHOCYTES[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-03
【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 LIU Hai-yun,TONG Jian,LI Jian-xiang*(Department of Health Toxicology,School of Radiology and Public Health,Medical College of Soochow University,Suzhou,Jiangsu 215123,China);Differences in Oxidative Damage and Gene Mutation between Smoking and Radon-induced Lung Cancer[J];Journal of Environmental & Occupational Medicine;2009-04
2 XU Nai-yu1,ZHANG Su-ping2,NIE Ji-hua2,et al(1.Department of Pharmacy,Suzhou University,Suzhou 215123 China;2.The Radiation and Public Health College of Suzhou University,The Key Laboratory of Radiation Medicine and Protection of Jiangsu Province,Suzhou 215123 China);Studies of Lymphatic Proteome of Rats exposed to Cigarette Smoke by Two-dimensional Gel Electrophoresis[J];Chinese Journal of Hemorheology;2007-02
3 LI Gui-rong,MA Yan-hui,ZHANG Ji,et al.(Department of Occupational and Environmental Health,School of Public Health,Peking University,Beijing,100083,China);A Study of Urinary 8-hydroxydeoxyguanosine(8-OHdG)as A Biomarker for Workers Exposed to Soluble Chromate[J];Preventive Medicine Tribune;2008-02
4 LIU Sheng-lin.(The Department of Examination,Xiqing Hospital in Tianjin,300380,China);The Progress of 8-hydroxy-2′-deoxyguanosine Detecting Method[J];Medical Recapitulate;2006-17
5 LIU Shan,SUN Gui fan,SUN Xian ce ,et al.School of Public Healt h,China Medical University(Shenyang 110000,China);DNA damage and repair of human lymphocytes treated with cigarette smoke solution[J];China Public Health;2004-01
6 Pan Hongzhi, Li Rong. Public Health School, Harbin Medical University, Harbin 150001, China;Detection of 8-hydroxy-2-deoryguanoslne,a marker for oxidative DNA damage[J];Chinese Journal of Health Laboratory Technology;2003-04
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Ai-hua, YANG Guang-hong, LI Jian, WANG Rong Department of Prevetive Medicine, Guiyang Medical College, Guiyang 550004, China;THE SITUATION OF DNA SYNTHESIS、 DNA DAMAGE AND DNA REPAIR IN ARSENISM PATIENTS BLOOD CELLS CAUSED BY COAL-BURNING[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;2000-02
2 MENG Zi qiang\+1, ZHANG Lian zhen\+2 (1. Institute of Environmental Medicine and Toxicology, Shanxi University, Taiyuan 030006,China; 2. China Institute for Radiation Protection, Taiyuan 030006, China);DNA OXIDANT DAMAGE INDUCED BY TOBACCO SMOKE IN HUMAN BLOOD LYMPHOCYTES[J];Carcinogenesis,Teratogenesis and Mutagenesis;2001-03
3 WU Jian-zhong, DING Jian-hua, GAO Chang-ming, LI Su-ping, ZANG Yu, ZHOU Jian-nong, SU Ping, LIU Yan-ting, ZHOU Xue-fu, WANG Ru-hong, DING Bao-guo(Department of Epidemiology, Jiangsu Institute of Cancer Research, Nanjing 210009, China);ALDEHYDE DEHYDROGENASE-2 GENOTYPES AND DRINKING BEHAVIOR OF CHINESE IN JIANGSU PROVINCE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-02
4 LIU Ru-qing+{1,2}, ZHUANG Zhi-xiong+1, HE Chun-hua+1, HE Yun+3(1. The Shenzhen Research Center of the Chinese Academy of Preventive Medicine, Shenzhen 518020, China; 2. Department of Environmental Health, the School of Public Health, Sun Yat-Sen Universil;RELATIONSHIP BETWEEN GENETIC POLYMORPHISMS OF HUMAN O~6-METHYLGUANINE-DNA METHYLTRANSFERASE (MGMT) GENE AND SUSCEPTIBILITY TO TUMORS[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-02
5 Ma Aiguo 1,Andrew R.Collins 2,Susan J.Duthie 2 1Department of Human Nutrition,Qingdao Medical College,Qingdao 266021, 2The Rowett Research Institute,U.K.;THE DIFFERENCES OF DNA DAMAGE AND REPAIR BETWEEN SEVERAL TYPES OF CELLS[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1997-03
6 WU Ji-zhou YEH Fu-sun MO Zhi-chun (Guangxi Cancer Institute China);A DETERMINATION OF THE AETIOLOGICAL FACTORS OF HEPATOCELLULAR CARCINOMA IN GUANGXI, CHINA-118pairs matched case-control study analysis by multiple conditional logistic regression model[J];Chinese Journal of Cancer;1990-01
7 DENG You ping, LIN Chen, ZHANG Xue yan, et al.National Laboratory of Molecular Oncology,Cancer Institute,Chinese Academy of Medical Sciences,Peking Union Medical College, Beijing 100021, P.R. China;Studies on arsenic trioxide induced human pulmonary adenocarcinoma GLC-82 cell apoptosis and its molecular mechanisms[J];CHINESE JOURNAL OF CANCER;1999-05
8 LIU Cha zhen, BIAN Jian chao* , SHEN Fu min, et al. Department of Epidemiology, Shanghai Medical University, Shanghai 200032, P.R.China;Genetic polymorphism of cytochrome P450 2E1and susceptibility to hepatocellular carcinoma[J];CHINESE JOURNAL OF CANCER;2000-10
9 ZHU Mao-xiang * ,YANG Zhi-hua,GONG Yi-fen,LU Ying,CAO Zhen-shan Institute of Radiatio n Medicine,Academy of Military Medical Science,B eijing 100850,P.R.Ch ina;Initiated Cancerazation Effect of Reactive Oxygen Species and Its Produ cts of Oxidative DNA Damage in B EP2D Cells[J];Chinese Journal of Cancer;2001-10
10 He Yong1,Fan Shi-Zhi1,Jiang Yao-Guang1,Chen Jian-Ming1,Li Zhi-Ping1,Zh ou Ping2,Zhou Yuan-Guo2 1.Thoracic Surgery Center of Peoples Liberation Army,The Third Military Medical University,Chongqing,400042,P.R.China 2.Department of Molecular Biology,Daping Hospital/Research Institute of Surgery,The Third Military Medical University,Chongqing,400042,P.R.China;Effect of p73 Gene on Chemosensitivity of Human Lung Adenocarcinoma Cells H1299[J];Chinese Journal of Cancer;2004-06
【Secondary References】
Chinese Journal Full-text Database 4 Hits
1 LI Peng-fei, FENG Jing-yu, YAN Ying-ying, FU Gang, SHEN Xiao-bing (Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China);Screening of Susceptibility Genes and Multi-gene Risk Analysis in Gastric Cancer[J];Journal of Environmental & Occupational Medicine;2011-09
2 LU Xiao-hua,ZHU Xiao-qing,MAO Guo-xin.Department of Interventional Radiology,Affiliated Hospital of Nantong University,Nantong 226001,China;Hepatocellular carcinoma-related single nucleotide polymorphisms: recent advances in research[J];Journal of Interventional Radiology;2013-06
3 SUN Yuanshe,HU Zhijian College of Public Health,Fujian Medical University,Fuzhou 350004,Chin;Meta-analysis of relationship between gene hOGG1 Ser326Cys polymorphism and hepatic carcinoma[J];Journal of Hygiene Research;2011-03
4 SU Shi-biao,JIN Ya-li,GUO Qiang-zhi,LI Xiao-liang,WEN Wei(Guangdong Prevention and Treatment Center for Occupational Disease,Guangzhou 510300,China);Level of 8-OHdG and hOGG1 among the residents in Yangjiang high background radiation area[J];China Occupational Medicine;2012-06
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