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《Carcinogenesis,Teratogenesis and Mutagenesis》 2005-02
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Inhibition of Tumor Cells by Ethanol Extract of Fomes Fomentarius

LIU Liang 1,2 ,ZHOU Shou-biao 1,ˇ ,ZHENG Wei-fa 2 (1.Provincial Key Laboratory of Conservation and Exploitation of Biological Resources in Anhui,Institute of Life Science,Anhui NormalUniversity,Wuhu Anhui241000,China;2.Provincial Key Laboratory of Biotechnology on Medical Plants,Xuzhou Jiangsu221116,China)  
BACKGROUNDAIM: To study the inhibition of tumor cells by ethanol extract of Fomes fomentarius(EEF)both in vivo and in vitro. MATERIAL AND METHODS: The influence of EEF on HeLa cells was assayed by MTT method.The effect of EEF on the apoptosis of S 180 cells was analysed by FCM.The effect of EEF on the extending rates of mice carrying S 180 tumor was investigated.MDA contents of several principle issues were observed,after the mice were dealed with EEF.RESULTS: EEF had obvious inhibitory activity to HeLa cells in vitro in a dose-dependent manner;could remarkably increase the apoptosis of S 180 cells,the extending rates of mice carrying S 180 tumor;MDA contents of liver,kindey were increased significantly,after the normal mice were treated by EEF. CONCLUSION: Ethanol extract of Fomes fomentarius has obvious inhibition on tumor cells.
【Fund】: 江苏省药物植物生物技术重点实验室重点项目(No.ZXL0512);; 重要生物资源保护与利用研究安徽省重点实验室专项基金
【CateGory Index】: R73-3
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