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《Carcinogenesis,Teratogenesis and Mutagenesis》 2005-04
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Experimental Study on the Anticancer Role of Acanthopanax Senticosus in the Invasion and Metastasis Process

ZHANG Jing-yi,XU Shun-jiang,YANG Hui-min,ZHANG Nai-zhe (Hebei Province Center for Disease Prevention and Control, Shijiazhuang050021,Hebei,China)  
BACKGROUNDAIM: To study the intervene role of acanthopanax sentiocosus(APS)in mice Lung during mice Lewis lung cancer. MATERIAL AND METHODS: Lewis lung cancer C57/BL mice were divided into acanthopanax senticasus+cyclophosphemide(CP),cyclophosphemide,acanthopanax sentiocosus and tumor groups.The tumor weight and inhibitory rate of each group were detected by elisa,PAI-1and uPA activation. RESULTS: The content of PAI-1,uPA of plasma and tumor,lung of APS group mice was significantly lower than tumor group in each time. CONCLUSION: APS exhibited intervention effects on the invasion and metastasis of cancer,and mice in APS plus CP group were getting better than APS alone group and CP alone group.
【Fund】: 河北省自然科学基金资助(No.399392)
【CateGory Index】: R734.2
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