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《Carcinogenesis,Teratogenesis and Mutagenesis》 2005-05
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The Anti-tumor in Vitro Effect of Cortex Periplocae and Its Analogues Extracted

SHAN Bao-en,LI Jun-xin,ZHANG Jing,LIANG Wen-jie,LI Hong-fen(Science and Research Center,The Fourth Hospital of Hebei Medical University,Hebei Shijiazhuang050011,China)  
BACKGROUNDAIM: Compare the anti-tumor effects of Cortex Periplocae and its analogues extracted in vitro. MATERIAL AND METHODS: We investigated the suppressive effect of Cortex Periplocae and its analogues extract on the proliferation of different tumor cells from human and mouse by using3-[4,5-dimethylthiazol-2-yl] -2,5diphenyl tetrazolium bromide(MTT)method. RESULTS: Cortex Periplocae extract markedly inhibited the proliferation of tumor cells such as K562,BGC-823,TE-13with dose-dependent manner.There exist markedly difference among Cortex Periplocae and its analogues extracts of their affect on the proliferation of different tumor cells from human and mouse(P0.01). CONCLUSION: Cortex Periplocae and its analogues extracts markedly inhibited the proliferation of many tumor cells in vitro,with dose-dependent manner;The Cortex Periplocae worked better than its analogues;Cortex Periplocae as anti-tumor substance is hoped advanced development.
【Fund】: 国家自然科学基金项目(No.30371753);; 河北省自然科学基金项目(No.C2004000610)
【CateGory Index】: R73-3
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