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《Carcinogenesis,Teratogenesis & Mutagenesis》 2006-01
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Study on the Teratogenicity of Erythromycin Propionate-N-Acetylcysteinate in Rats

PAN Jing-yuan,QIU Yin-sheng,YAN Han-chi,LING Sa (Center of Pharmacology and Toxicology,Hubei Pharmaceutical Industry Research Institute,Wuhan430061,Hubei,China)  
BACKGROUNDAIM: To investigate the teratogenicity of erythromycin propionate-N-acetylcysteinate(EPAC)in rats. MATERIAL AND METHODS: SD rats were used in this teratogenicity study.On days6-15of pregnancy,SD rats received the drug in three doses of75,200,and400mg/kg. RESULTS: After oral administration of EPAC,pregnant rats in the groups of200and400mg/kg doses had signs of anorexia,and decreased activity.The results showed that the body weight gains of pregnant rats on days10-13were significantly lower in the groups of the doses of200and400mg/kg than in the control group,and recovered to normal after the withdrawal of the drug.The fertility of pregnant rats was not different in each group compared with the control group.No morphologic malformation of rat fetuses was observed in each group compared with those in the control group.The body length and tail length of rats were not significantly different in each group.No abnormality was observed in the growth of bones and internal organs in rat fetuses in all groups. CONCLUSION: EPAC in the doses of200and400mg/kg has maternal toxicity in pregnant rats,characterized by decreased body weight and anorexia,but has no fetal toxicity or teratogenicity.
【Fund】: 湖北省重点科技项目(2000LP1602)
【CateGory Index】: R96
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【Co-citations】
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1 LIANG Hai-ying, ZHANG Xiao yuan, LIANG Song ping (Laboratory of Protein Chemistry, College of Life sciences, Hunan Normal University, Changsha 410081, China);THE STUDY ON MUTAGENICITY OF HUWEN ANALGESIC PEPTIDE[J];Carcinogenesis,Teratogenesis and Mutagenesis;2002-03
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3 MEI Shu-jiang,LIU Ya,WANG Bao- Gui,et al(1.Department of biiology,Shantou University Medical College,Shantou 51503 1,China;2.College o f Preventive Medicine,Jilin University,Changchun 130021, China;3.Health Supervision Office of Changchun Health Bureau Changchun 130021,China);STUDY ON ACUTE TOXICITY AND MUTAGENTICITY OF POLYOXOANIONS α-K_8H_2[SiW_9Ti_3O_40]·15H_2O[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-03
4 LIAO Xue1, WANG Jie1, SONG Hong-yu1, et al(1.National Research Center for New Drug Safety Evaluation ,Shenyang 110021,China;2.The Ninth Hospital of Shenyang, shenyang 110024,China);STUDY OF TER ATOGENICITY OF PIOGILISTAZONE HYDROCHLORIDA IN RATS[J];Carcinogenesis,Teratogenesis and Mutagenesis;2003-04
5 YU Yan 1 ,LIN Fei 2 ,ZHANG Rui-juan 1 ZHANG Zhen-jun 1 ,LI An-jing 1 (1.College of Medical Science,Xi'an Jiaotong University,Xi'an 710061,Shanxi China;2.Assessment Institute of Drugs and Biology Products of China,Beijing100050,China);The Toxicity Study of Recombinant Human Glucagon-like Peptide on Rats During the Period of Sensitive Teratogenesis[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-03
6 LIN Fei 1 ,LU Lian 1 ,YANG Xu-qing 2 ,CUI Wei-chuan 2 ,WANG Feng-min 2 (1.National Institute for the Control of Pharmaceutical and Biological Products,Beijing100050,China;2.The Science System Corporation of Beijing Xingda,Beijing100081,China);The Comparison Study of Major Target Organ Hurt Induced by Dicycloplatin and Its Derivates in Rats[J];Carcinogenesis,Teratogenesis and Mutagenesis;2005-05
7 SUN Xiao-ying 1 ,ZHANG Zhen-jun 1 ,BIAN Xue-feng 2 , CHEN Qing 1 ,YU Yan 1 (1.Department of Environmental Health,Xi'an Jiaotong University,Xi'an710061,China;2.Department of Health Statistics,Xi'an Jiaotong University,Xi'an710061,Shaanxi, China);Study on the Teratogenic Effects of Pseudoephedrine in Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-01
8 WEI Xian-fei,TANG Rong-lan,GAN Yun-sheng,LUO Feng-jiao (Liuzhou Medical College, Liuzhou, Guangxi 545006, China);The Toxicity Attenuation and Antimutagenic Effect of Health-preserving Cigarettes Made From Chinese Herbal Medicine[J];Carcinogenesis,Teratogenesis & Mutagenesis;2007-01
9 LU Jing-tao1,XU De-xiang2,SUN Mei-fang2,WEI Ling-zhen2,SHEN Tong1,WEI Wei1(1.Institute of Clinical Pharmacology;2.Department of Toxicology,Anhui Medical University,Hefei 230032,China);Study on Teratogenicity of Glycosides of Chaenomeles Speciossa[J];Carcinogenesis,Teratogenesis & Mutagenesis;2008-01
10 LIU Li-li,DENG Ying-yu,SONG Xiang-rong,CHEN Xiao-yan,HUANG Jian-xun(Department of Toxicology,Guangdong Provincial Hospital for Occupational Diseases Control,Guangzhou 510300,Guangdong,China);Teratogenicity of 1-chloromethylsilatrane in Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2009-01
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 ZHOU Yi-ping,CHEN Qi-you,CHEN Si-yan,YANG Jing-hua (Hubei Pharmaceutical Industry Research Institute, Wuhan430061,China);Teratogenicity of Arbidol Hydrochloride in Rats[J];Carcinogenesis,Teratogenesis & Mutagenesis;2006-01
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【Secondary References】
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