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《Carcinogenesis,Teratogenesis & Mutagenesis》 2006-01
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Study on the Teratogenicity of Erythromycin Propionate-N-Acetylcysteinate in Rats

PAN Jing-yuan,QIU Yin-sheng,YAN Han-chi,LING Sa (Center of Pharmacology and Toxicology,Hubei Pharmaceutical Industry Research Institute,Wuhan430061,Hubei,China)  
BACKGROUNDAIM: To investigate the teratogenicity of erythromycin propionate-N-acetylcysteinate(EPAC)in rats. MATERIAL AND METHODS: SD rats were used in this teratogenicity study.On days6-15of pregnancy,SD rats received the drug in three doses of75,200,and400mg/kg. RESULTS: After oral administration of EPAC,pregnant rats in the groups of200and400mg/kg doses had signs of anorexia,and decreased activity.The results showed that the body weight gains of pregnant rats on days10-13were significantly lower in the groups of the doses of200and400mg/kg than in the control group,and recovered to normal after the withdrawal of the drug.The fertility of pregnant rats was not different in each group compared with the control group.No morphologic malformation of rat fetuses was observed in each group compared with those in the control group.The body length and tail length of rats were not significantly different in each group.No abnormality was observed in the growth of bones and internal organs in rat fetuses in all groups. CONCLUSION: EPAC in the doses of200and400mg/kg has maternal toxicity in pregnant rats,characterized by decreased body weight and anorexia,but has no fetal toxicity or teratogenicity.
【Fund】: 湖北省重点科技项目(2000LP1602)
【CateGory Index】: R96
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