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《Carcinogenesis,Teratogenesis & Mutagenesis》 2006-01
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The Relationship Between COX-2,MDR-1(P-gp)Expression and Gastric Carcinogenesis in Helicobacter Pylori Positive Gastric Mucosa

MA Xiu-mei 1 ,WANG Yu-fang 2 ,GENG Li-ping 2 ,ZUO Lian-fu 1,ˇ (1.Hebei Provincial Tumor Institute,The Fourth Affiliated Hospital of Hebei Medical University,Shijiazhuang050011,Hebei,China; 2.Department of Pathology,Inner Mongolia Medical College,Huhhot,010059,The Inner Mongolia Autonomous Region,China)  
BACKGROUNDAIM: To explore the mechanism of Helicobacter Pylori(H.pylori)-related gastric carcinogenesis and overexpression of the multidrug-resistant-1(MDR-1)gene-encoded P-glycoprotein(P-gp)via examining Cyclooxygenase-2(COX-2)and P-gp expression in the affected gastric mucosa. MATERIAL AND METHODS: 155chronic gastritis specimens(30chronic superficial gastritis specimens,40chronic atrophic gastritis specimens,45intestinal metaplasia specimens,40dysplasia specimens)and80gastric carcinoma specimens(40intestinal type and40diffuse type)were selected.COX-2and P-gp expression were detected by immunohistochemistry.H.pylori infection was assessed by rapid urease test and histological examination(modified Giemsa staining). RESULTS: H.pylori infection rate,COX-2positive expression rate and P-gp positive expression rate in intestinal-type gastric carcinoma specimens were significantly higher than those in diffuse-type gastric carcinoma specimens(P0.01).Expression of COX-2was positively correlated with H.pylori infection in chronic atrophic gastritis,intestinal metaplasia,dysplasia and intestinal-type gastric carcinoma(P0.01).Expression of COX-2was positvely correlated with that of P-gp in chronic superficial gastritis,chronic atrophic gastritis,intestinal metaplasia,dysplasia,and intestinal-type gastric carcinoma with H.pylori infection(P0.01). CONCLUSION: H.pylori-dependent induction of COX-2was associated with enhanced prodution of P-gp that might contribute to gastric tumourigenesis and resistance to chemotherapy.
【CateGory Index】: R735.2
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