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《Carcinogenesis,Teratogenesis & Mutagenesis》 2006-01
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Study on the Teratogenic Effects of Pseudoephedrine in Rats

SUN Xiao-ying 1 ,ZHANG Zhen-jun 1 ,BIAN Xue-feng 2 , CHEN Qing 1 ,YU Yan 1 (1.Department of Environmental Health,Xi'an Jiaotong University,Xi'an710061,China;2.Department of Health Statistics,Xi'an Jiaotong University,Xi'an710061,Shaanxi, China)  
BACKGROUNDAIM: This study was undertaken to determine the potential teratogenic effects of Pseudoephedrine on SD rats and to provide toxicological information. MATERIAL AND METHODS: SD pregnant rats were randomly divided into four groups:Pseudoephedrine50,100,200mg/kg and control.Conventional teratogenicity test was performed.Female rats was given Pseudoephedrine by gastric intubation at50,100,200mg/kg on days6-15of gestation. RESULTS: Adjusted weight gain of pregnant rats,body weight of fetuses and the number of dead fetuses were significantly different at200mg/kg when compared to controls. CONCLUSION: Among the range of experimental doses,pseudoephedrine was considered to have maternal toxicity,embryo toxicity and teratogenic effects in SD rats.
【CateGory Index】: R96
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