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《Carcinogenesis,Teratogenesis & Mutagenesis》 2006-04
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The Effect of HPP on Abnormal Expression of Mice Hepatic Cells POD and Caspase-3

ZHU Yong_mei,ZHONG Jin_yi ˇ ,ZHANG Li_hua (Institute of Nutrition,Medical College of Qingdao University,Qingdao266021,Shandong,China)  
BACKGROUNDAIM: To study the effect of(Haishen polysaccharide peptide,HPP)on the apoptosis and apoptosis gene of mice hepatic cells induced by 60 Co_γirradiation. MATERIAL AND METHODS: Mice were fed150mg/kg and100mg/kg HPP for four weeks.Mice were then irradiated with 60 Co_γto induce hepatic cells apoptosis once a day five days a week.Four weeks later,in situ cell death detection kit and in situ hybridization were applied to measure qualitative changes at expression level of POD and Caspase_3positive cells rate to analyze the apoptosis of mice hepatic cells. RESULTS: The rates of POD and Caspase_3expression in the radiation_injury group were(40.0±3.5)%and(26.0±1.2)%,respectively,and the rates of the high dose group were(23.9±3.8)%and(6.0±1.5)%,respectively,the difference between the radiation_injury group and high dose group showed statistical significance(P0.01). CONCLUSION: HPP had a significant inhibitory effect on the abnormal hepatic expression of POD and Caspase_3induced by radioactive damage.
【Fund】: 山东省科技厅基金资助项目(No.031070114)
【CateGory Index】: R285
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