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《Carcinogenesis,Teratogenesis & Mutagenesis》 2006-05
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The Anti-tumor Effect and Immunoregulatory Activity of PE2 From Rhizoma Menipermi Extracts in Vivo

SHAN Bao-en1,LIU Dong-qing2,LIANG Wen-jie1,ZHANG Jing1,LI Qiao-xia1(1.Research Center of the Fourth Hospital of Hebei Medical University,Shijiazhuang,050011,China;2.The First Hospital of Handan)  
BACKGROUND AIM: To study the antitumor activity and immunoregulatory activity of Chinese medicinal herb Rhizoma Menipermi extracts in vivo. MATERIAL AND METHODS: The chemical composition of Rhizoma Menipermi extract was separated with water,ethanol extraction and distillation methods. The suppressive effect of Rhizoma Menipermi extracts on the proliferation of tumor cells were assayed in vitro using MTT colorimetric method. The effect of Rhizoma Menipermi extracts on lymphocytes and the effect on the phagocytosis of mouse peritoneal macrophages were studied using MTT colorimetric method and neutral red method. The tumor bearing mouse model was constructed by injecting tumor cells subcutaneously. Then PE2 from Rhizoma Menipermi extract was given to the mouse orally to observe its antitumor activity and immunoregulatory activity in vivo. RESULTS: Rhizoma Menipermi extracts RMW and RME markedly inhibited the proliferation of tumor cells such as K562. The effect of RME was stronger than RMW.The PE2 constituent purified from RME might be the main antitumor active part of Rhizoma Menipermi as shown by antitumor test in vitro. After treatment with PE2,the general condition of the test mice was much better than that of control mice,with tumor growing more slowly and life prolonged. CONCLUSION: PE2 might be the main antitumor active part of Rhizoma Menipermi. PE2 also had antitumor effect in vivo. PE2 could exert antitumor effect in vivo by enhancing the phagocytosis of macrophages and by enhancing NK cells activity.
【Key Words】： Rhizoma Menipermi extracts antitumor activity immunoregulatory activity spleen cells macrophages
【Fund】： 国家自然基金 (C03050205);; 河北省自然基金(C2004000610)
【CateGory Index】： R285
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