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《Carcinogenesis,Teratogenesis and Mutagenesis》 2007-01
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Experimental Study of Achillea Millefolium L.Extract on Hepatic Injury and Chronic Hepatic Fibrosis

HONG Zhen-feng,CHEN Yan-hua,ZHOU Jian-heng,LI Tian-jiao (Department of Traditional and Western Medicines, Fujian College of TCM, Fuzhou,350003,Fujian,China)  
BACKGROUND AIM: To study the anti-hepatofibrotic effect of the Achillea millefolium L.(Aml) extract on experimental hepatic fibrosis and its partial mechanism. MATERIALS AND METHODS: The hepatic fibrosis rat model was developed by subcutaneous injection of 40%CCl 4 (5 ml/kg) and rats were treated with extract of Aml at 3 ml/kg, 6 ml/kg or 12 ml/kg. Alanine aminotransferase(ALT),aspartate aminotransferase(AST)levels were measured and liver tissue examined for pathological changes after HE staining. RESULTS: The extract of Aml could reduce the abnormally high levels of ALT and AST. Examined by light microscope,the degeneration and necrosis level of hepatocytes and the distribution of collagen fibrosis were markedly increased in the model group. The pathological changes and the c ollagen fibrosis associated with hepatic fibrosis decreased significantly in the prophylactically treated groups. CONCLUSION: Extract of Aml could protect hepatocytes from injury and prevent the progression of hepatic fibrosis in rats.
【Fund】: 福建省科技三项费用资助(NoK02086)
【CateGory Index】: R285.5
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Jiang Xuelian, Ben Changen, Yu Shiying, et al.(Beijing University of Traditional Chinese Medicine, Beijing 100029);Experimental Study on the Prevention and Treatment of Hepatic Fibrosis with the TCM Decoction[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1999-03
【Co-references】
Chinese Journal Full-text Database 2 Hits
1 WANG Sheng Chun 1, WANG Ling 2, TIAN Wei Bin 1, ZHAO Hui Ping 2 1Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xi'an 710033, China, 2Boai Pharmaceutical Limited Company, Xi'an 710068, China;Effects of Chaihu and Wulingwan on chronic liver lesion in mice[J];Journal of The Fourth Military Medical University;2002-02
2 ZHENG Zuo wen1, ZENG Chun hui1, LIN Ying hui2 (1.Faculty of Pharmaceutical Science, Guangxi Traditional Chinese Medical University,Nanning 530001; 2. The No 1 Affiliated Hospital to Guangxi Traditional Chinese Medical University,Nanning 530023);The Protective Effect of APS against Acute Chemical liver Injury of the Mouse[J];Journal of Guangxi College of T.c.m;2002-03
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 Cao Xianying (曹献英), Ben Chang'en (贲长恩), Yu Shiying (于世嬴)(Teaching and Research Section for Histology and Embryology, Beijing University of Traditional Chinese Medicine, Beijing 100029);Histochimical and Serological Study on the Treatment of Rat Hepatic Fibrosis with Drugs for Promoting Blood Circulation and Removing Stasis[J];JOURNAL OF BEIJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE;1998-02
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