Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Carcinogenesis,Teratogenesis & Mutagenesis》 2007-03
Add to Favorite Get Latest Update

Expression of FHIT and p16 in Non-small Cell Lung Cancers

WANG Ping1,ZHANG Qing2,WANG Zu-yi2,CHENG Ze-nong1,YU Dong-hong1,WU Shi-wu1(1.Department of Pathology,Bengbu Medical College,Bengbu 233030,Anhui;2.Central Laboratory,Affiliated Hospital of Bengbu Medical College,Bengbu 230004,Anhui,China)  
BACKGROUND AIM:To investigate the expression of fragile histidine triad(FHIT)and p16 in non-small cell lung cancers(NSCLCs)and their relationships with clinicopathological factors.MATERIALS AND METHODS:Eighty cases of NSCLCs were examined for expression of FHIT and p16 by immunohistochemical SP method.RESULTS:54(67.5%)and 63(78.75%)of 80 patients revealed loss of or markedly reduced protein expression of FHIT and p16,respectively.Aberrant expression of FHIT was noted in most squamous(25 out of 55)and in a small fraction of adenocarcinomas(3 out of 23;P0.01),and more frequently in male patients than female patients.Notably,loss of p16 expression was associated with lymph node metastasis.CONCLUSION:Our results suggested that abnormal expressions of FHIT and p16 gene might occur early and play important roles in lung tumorigenesis and correlate with its prognosis.However,further studies are needed to confirm the influence of FHIT and p16 in the biologic behavior of the tumor.
【Fund】: 安徽省教育厅自然科学研究项目(2002kj220)
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 2 Hits
1 YIN Xiaomin1,WEN Chunyan2,HAN Yuling2,GAO Yijun2,TANG Zhangui3(1.Department of Stomatology,Xiangya Hospital,Central South University,Changsha,410078;2.Department of Stomatology,Second Xiangya Hospital,Central South University,Changsha 410011;3.Department of Oral and Maxillofacial Surgery,Xiangya Hospital,Central South University,Changsha 410078,China);Expression of FHIT and MDM2 in oral submucous fibrosis and canceration tissues[J];Journal of Central South University(Medical Science);2010-06
2 ZENG Zhihui(Department of Respiratory Medicine,Yuanjiang People's Hospital,Yuanjiang 413100,China);FHIT expression and the relationship with expressions of Survivin and Ezrin proteins in non-small cell lung cancer[J];China Medical Herald;2010-20
Chinese Journal Full-text Database 2 Hits
1 ZHAO Po, LU Yali, ZHONG Mei, CHEN Lezhen. Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, P.R.China;Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer[J];Chinese Journal of Lung Cancer;2002-05
2 WANG Xingyuan, SUN Yan, LI Weidong et al. Department of Medical Oncology, National Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes[J];CHINESE JOURNAL OF ONCOLOGY;1999-02
Chinese Journal Full-text Database 10 Hits
1 LI Dian-ming~1,LIU Chao~1,CHEN Yu-qing~1,XIA Xue-mei~1,HUANG Li-nian~1,LI Bai-qing~2(1.Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Bengbu 233004;2.Department of Immunology,Bengbu Medical College,Bengbu 233003,China);Expression of survivin mRNA in lung cancer tissue and its relationship with prognosis[J];Journal of Bengbu Medical College;2005-03
2 CHANG Xiujun, YANG Sheng, ZHANG Haiqing, WANG Hui, JIANG Ying. Department of Thoracic Surgery, Tuberculosis and Thoracic Tumor Research Institute of Beijing, Beijing 101149, P.R.China;Expression of FHIT gene in precancerous lesions and primary lung cancer tissues[J];Chinese Journal of Lung Cancer;2006-04
3 GUO Xiang-yun MA Li-ya LIU Xiao-xia (Department of Occupational Disease,People's Hospital of Gansu Province,Lanzhou 730000,China);The Expressions of P53,P21~(WAF/CIP1) and Cyclin D1 in Lung Tissue of Mice Treated with Bitumen Fume[J];Journal of Environmental & Occupational Medicine;2008-02
4 HUO Xiao-dong, Li Guo-hua (Inner Mongolia Medical College, Hohhot 010059 China);THE RESEARCH PROGRESS OF BIOLOGICAL BEHAVIOUR OF PRIMARY CANCER AND METASTATIC CANCER[J];Acta Academiae Medicinae Neimongol;2005-02
5 L Ya-li,SHAO Yun,ZHONG Mei,LI Xiang-hong,ZHAO Po Department of Pathology,Chinese PLA General Hospital,Beijing 100853,P.R.China;Clinicopathological significance of expression of fragile histidine triad protein in neuroendocrine lung carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-04
6 TONG Sheng-chun,ZHANG Yan,WANG Yong-lai.The Second Affiliated Hospital of China Medical University,Shenyang 110032,China;The expression and significana of fragile histidine triad protein and proliferating cell nuclear antigen in endometrial carcinoma[J];Shanxi Medical Journal;2008-02
7 LI Dian-ming, XIA Xue-mei, LIU Chao, CHEN Yu-qing, CAI Ying-yun. Department of Respiratory Diseases, Affiliated Hospital, Bengbu Medical College, Bengbu 233004, China;The significance of FHIT gene detection for the diagnosis of lung cancer in transbronchial biopsy tissue samples and sputum samples[J];The Journal of Practical Medicine;2008-21
8 YU Yong-chun, SUN Fen-yong, LI Zhi, LU Shao-yi, TENG Xiao-hong. "Center Laboratory, Railway Hospital Affiliated to Tongji University, Shanghai 200072, China;Relationship between aberrant FHIT transcripts and hepatocellular carcinoma[J];Chinese Journal of Hepatology;2003-09
9 CHEN Ping1, LI Jian2, YIN Kai-sheng1, YU Li-chao3 (1. Department of Respiration, the First Affilicated Hospital of Nanjing Medical University, Nanjing 210029; 2.Department of Respiration 3.Department of Chest, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001,China);Studies On the Deletion of p16 Gene in Non-small Cell Lung Cancer[J];Journal of Zhenjiang Medical College;2004-02
10 CHEN Ping,LI Jian,HANG Jian-ming,ZHAO Xi-wu,ZHANG Lan-shi(Department of Respiratory Medicine,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu 212001,China);Detection of FHIT deletion in tissues obtained by fiberoptic bronchoscopy and its diagnostic value of lung cancer[J];Journal of Jiangsu University(Medicine Edition);2006-06
Chinese Journal Full-text Database 10 Hits
1 CAI Sheng rong,FANG Zhi bin,HUANG Kai quan,WANG Yuan xun (Department of Integrated Traditional and Western Medicine, Anhui College of Traditional Chinese Medicine, Anhui Heifei 230038, China);Research on Relativity between Hemorrheology Indexes and the Levels of Endothelin and Thromboxane B_2 in Rats with Lung Qi Deficiency Syndrome[J];Journal of Anhui Traditional Chinese Medical College;2003-05
2 WANG Tao1*, JIN Ge2, WANG Shu mei1, et al 1 Department of Respiratory Medicine, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, P R China 2 The School of Basic Medical Sciences, Henan Medical University, Zhengzhou 450052,;Induced differentiation of human lung adenocarcinoma cells by cinnamic acid[J];CHINESE JOURNAL OF CANCER;2000-08
3 AN Qian, DONG Xiang-yang, ZHANG Jian-jun, HUANG Jin-feng, LI Li, CHENG Shu-jun, GAO Yan-ning (Cancer Institute (Hospital), Peking Union Medical College/ Chinese Academy of Medical Sciences, Beijing 100021, P. R. China);Studies on Inactivation of p16/CDKN2 Gene in Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2001-06
4 LIU Fu-Xing1,2,HUANG Xiao-Ping1,ZHAO Chun-Xia1,XU Xin1,HAN Ya-Ling1,CAI Yan1,WU Ren-Liang2,WU Min1,ZHAN Qi-Min1,WANG Ming-Rong1 1.National key Laboratory of Molecular Oncology,Cancer Institute(Hospital),Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing,100021,P.R.China 2.Department of Pathology,Tongji Medical College,Huazhong University of Science & Technology,Wuhan,Hubei,430030,P.R.China;Allelic Loss and Down-Regulation of FHIT Gene Expression in Esophageal Squamous Cell Carcinoma[J];Chinese Journal of Cancer;2004-09
5 Zhang Yaozhou Wu Xiangfu Li Zaiping(Shanghai Institute of Biochemistry, Academia Sinica, Shanghai, 200031);EXPRESSION OF CAT GENE UNDER THE CONTROL OF P10 GENE PROMOTER FROM BOMBYX MORI NUCLEAR POLYHEDROSIS VIRUS[J];Chinese Journal of Virology;1993-04
6 GU Jian-qi, ZHANG Ying-huai, YANG Wei. People's Hospital of Hebei Province, Shijiazhuang 050000, China;Expression and significance of FHIT in oral squamous cell carcinoma[J];Beijing Journal of Stomatology;2006-04
7 Bai Jianshi Wang Ping Ma Qing Yan Fang He Zhongxiao(College of Life Science, Beijing Normal University, 100875, Beijing, China);EFFECT OF S-ADENOSYL- L-METHIONINE (SAM) ON GROWTH AND DIFFERENTIATION OF HL-60 CELLS[J];Journal of Beijing Normal University(Natural Science);2000-06
9 YANG Zhen-zhou1,ZENG Lin-li1,ZHANG Yun-song2,et al.(1.Center of Oncology;2.Cardiothoracic Surgery;3.Department of Pathology,Daping Hospital,Third Military Medical University,Chongqing 400042,China);Relationship between expressive variation of APE1 and therapeutic effect by PDT in NSCLC[J];Chongqing Medicine;2009-20
10 LIU Zan1,LI Hui2,MA Wen-jing1,CHEN Yan2,LV Guo-dong1,PANG Zuo-liang3,WANG Hong-jiang3,ZHOU Xin4,ZHAO Xue-xin2,LI Hui-wu2(1.The 1st Affiliated Hospital,Xinjiang Medical University,Urumqi,Xinjiang 830054,China;2.Pre-clinic College,Xinjiang Medical University,Urumqi,Xinjiang 830054,China;3.Affiliated Tumor Hospital,Xinjiang Medical University,Urumqi,Xinjiang 830011,China;4.Urumqi General Hospital of Lanzhou Command,PLA,Urumqi,Xinjiang 830000,China);Expression and Significance of Cdc42 and Rb Gene in Kazak′s Esophageal Cancer[J];Endemic Diseases Bulletin;2008-04
【Secondary References】
Chinese Journal Full-text Database 2 Hits
1 YANG Nuo,XIAN Lei,CHEN Ming-wu,GUO Jian-ji,WANG Ling-ping,XU Hui-hang(Department of Cardiothoracic Surgery,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Expression of Bcl-2 Protein in Non-small Cell Lung Cancer and its Clinical Significance[J];Guangxi Medical Journal;2011-05
2 LIU Wen-shu1,XU Ya-juan2.(1.Dental Departments of First Hospital Norman Bethune of Jilin University,Changchun,Jilin Province 130021;2.Dental Departments of Tumor Hospital,Jilin Province);Expression of FHIT in buccal squamous cell carcinoma and its clinical significance[J];Chinese Journal of Laboratory Diagnosis;2010-11
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Jun, ZHOU Qinghua, QIN Yang, SUN Zhilin, SUN Zefang, WANG Yun, LI Lu, QIN Jianjun. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R.China;A study on transcript abnormalities of FHIT gene in human non small cell lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-04
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved