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《Carcinogenesis,Teratogenesis & Mutagenesis》 2007-03
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Expression of FHIT and p16 in Non-small Cell Lung Cancers

WANG Ping1,ZHANG Qing2,WANG Zu-yi2,CHENG Ze-nong1,YU Dong-hong1,WU Shi-wu1(1.Department of Pathology,Bengbu Medical College,Bengbu 233030,Anhui;2.Central Laboratory,Affiliated Hospital of Bengbu Medical College,Bengbu 230004,Anhui,China)  
BACKGROUND AIM:To investigate the expression of fragile histidine triad(FHIT)and p16 in non-small cell lung cancers(NSCLCs)and their relationships with clinicopathological factors.MATERIALS AND METHODS:Eighty cases of NSCLCs were examined for expression of FHIT and p16 by immunohistochemical SP method.RESULTS:54(67.5%)and 63(78.75%)of 80 patients revealed loss of or markedly reduced protein expression of FHIT and p16,respectively.Aberrant expression of FHIT was noted in most squamous(25 out of 55)and in a small fraction of adenocarcinomas(3 out of 23;P0.01),and more frequently in male patients than female patients.Notably,loss of p16 expression was associated with lymph node metastasis.CONCLUSION:Our results suggested that abnormal expressions of FHIT and p16 gene might occur early and play important roles in lung tumorigenesis and correlate with its prognosis.However,further studies are needed to confirm the influence of FHIT and p16 in the biologic behavior of the tumor.
【Fund】: 安徽省教育厅自然科学研究项目(2002kj220)
【CateGory Index】: R734.2
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Chinese Journal Full-text Database 2 Hits
1 ZHAO Po, LU Yali, ZHONG Mei, CHEN Lezhen. Department of Pathology, Chinese General Hospital of People's Liberation Army, Beijing 100853, P.R.China;Clinicopathological analysis of loss of fragile histidine triad expression in lung cancer[J];Chinese Journal of Lung Cancer;2002-05
2 WANG Xingyuan, SUN Yan, LI Weidong et al. Department of Medical Oncology, National Laboratory of Molecular Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;Alterations of FHIT gene and p16 gene in lung cancer and metastatic hilar lymph nodes[J];CHINESE JOURNAL OF ONCOLOGY;1999-02
Chinese Journal Full-text Database 10 Hits
1 LI Dian-ming~1,LIU Chao~1,CHEN Yu-qing~1,XIA Xue-mei~1,HUANG Li-nian~1,LI Bai-qing~2(1.Department of Respiratory Diseases,Affiliated Hospital of Bengbu Medical College,Bengbu 233004;2.Department of Immunology,Bengbu Medical College,Bengbu 233003,China);Expression of survivin mRNA in lung cancer tissue and its relationship with prognosis[J];Journal of Bengbu Medical College;2005-03
2 CHANG Xiujun, YANG Sheng, ZHANG Haiqing, WANG Hui, JIANG Ying. Department of Thoracic Surgery, Tuberculosis and Thoracic Tumor Research Institute of Beijing, Beijing 101149, P.R.China;Expression of FHIT gene in precancerous lesions and primary lung cancer tissues[J];Chinese Journal of Lung Cancer;2006-04
3 GUO Xiang-yun MA Li-ya LIU Xiao-xia (Department of Occupational Disease,People's Hospital of Gansu Province,Lanzhou 730000,China);The Expressions of P53,P21~(WAF/CIP1) and Cyclin D1 in Lung Tissue of Mice Treated with Bitumen Fume[J];Journal of Environmental & Occupational Medicine;2008-02
4 HUO Xiao-dong, Li Guo-hua (Inner Mongolia Medical College, Hohhot 010059 China);THE RESEARCH PROGRESS OF BIOLOGICAL BEHAVIOUR OF PRIMARY CANCER AND METASTATIC CANCER[J];Acta Academiae Medicinae Neimongol;2005-02
5 L Ya-li,SHAO Yun,ZHONG Mei,LI Xiang-hong,ZHAO Po Department of Pathology,Chinese PLA General Hospital,Beijing 100853,P.R.China;Clinicopathological significance of expression of fragile histidine triad protein in neuroendocrine lung carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2008-04
6 TONG Sheng-chun,ZHANG Yan,WANG Yong-lai.The Second Affiliated Hospital of China Medical University,Shenyang 110032,China;The expression and significana of fragile histidine triad protein and proliferating cell nuclear antigen in endometrial carcinoma[J];Shanxi Medical Journal;2008-02
7 LI Dian-ming, XIA Xue-mei, LIU Chao, CHEN Yu-qing, CAI Ying-yun. Department of Respiratory Diseases, Affiliated Hospital, Bengbu Medical College, Bengbu 233004, China;The significance of FHIT gene detection for the diagnosis of lung cancer in transbronchial biopsy tissue samples and sputum samples[J];The Journal of Practical Medicine;2008-21
8 YU Yong-chun, SUN Fen-yong, LI Zhi, LU Shao-yi, TENG Xiao-hong. "Center Laboratory, Railway Hospital Affiliated to Tongji University, Shanghai 200072, China;Relationship between aberrant FHIT transcripts and hepatocellular carcinoma[J];Chinese Journal of Hepatology;2003-09
9 CHEN Ping1, LI Jian2, YIN Kai-sheng1, YU Li-chao3 (1. Department of Respiration, the First Affilicated Hospital of Nanjing Medical University, Nanjing 210029; 2.Department of Respiration 3.Department of Chest, the Affiliated Hospital of Jiangsu University, Zhenjiang Jiangsu 212001,China);Studies On the Deletion of p16 Gene in Non-small Cell Lung Cancer[J];Journal of Zhenjiang Medical College;2004-02
10 CHEN Ping,LI Jian,HANG Jian-ming,ZHAO Xi-wu,ZHANG Lan-shi(Department of Respiratory Medicine,the Affiliated Hospital of Jiangsu University,Zhenjiang Jiangsu 212001,China);Detection of FHIT deletion in tissues obtained by fiberoptic bronchoscopy and its diagnostic value of lung cancer[J];Journal of Jiangsu University(Medicine Edition);2006-06
Chinese Journal Full-text Database 10 Hits
1 CAI Sheng rong,FANG Zhi bin,HUANG Kai quan,WANG Yuan xun (Department of Integrated Traditional and Western Medicine, Anhui College of Traditional Chinese Medicine, Anhui Heifei 230038, China);Research on Relativity between Hemorrheology Indexes and the Levels of Endothelin and Thromboxane B_2 in Rats with Lung Qi Deficiency Syndrome[J];Journal of Anhui Traditional Chinese Medical College;2003-05
2 WANG Tao1*, JIN Ge2, WANG Shu mei1, et al 1 Department of Respiratory Medicine, the First Affiliated Hospital, Henan Medical University, Zhengzhou 450052, P R China 2 The School of Basic Medical Sciences, Henan Medical University, Zhengzhou 450052,;Induced differentiation of human lung adenocarcinoma cells by cinnamic acid[J];CHINESE JOURNAL OF CANCER;2000-08
3 AN Qian, DONG Xiang-yang, ZHANG Jian-jun, HUANG Jin-feng, LI Li, CHENG Shu-jun, GAO Yan-ning (Cancer Institute (Hospital), Peking Union Medical College/ Chinese Academy of Medical Sciences, Beijing 100021, P. R. China);Studies on Inactivation of p16/CDKN2 Gene in Non-Small Cell Lung Cancer[J];Chinese Journal of Cancer;2001-06
4 GU Jian-qi, ZHANG Ying-huai, YANG Wei. People's Hospital of Hebei Province, Shijiazhuang 050000, China;Expression and significance of FHIT in oral squamous cell carcinoma[J];Beijing Journal of Stomatology;2006-04
6 LIU Xue Ying 1, ZHAO Yue Ping 2, JIANG Yong Pei 2,TANG Hai Feng 2 1Department of Pharmaceutics, Tangdu Hospital,Xi'an 710038, 2Department of Pharmaceutics, Xijing Hospital, Fourth Military Medical University;Effect of ethyl acetate extract of Eclipta prostrata on the function of T lymphocyte[J];Journal of The Fourth Military Medical University;2001-08
7 LIN Jing-ming1, LIU Yu1, LUO Rong-cheng2 1Department of Pharmacy, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China;2Oncology Center, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;Effect of Scutellaria barbata extract against human hepatocellular Hep-G2 cell proliferation and its mechanism[J];Journal of Southern Medical University;2006-07
9 JING Hui, BAI Xiu-zhen, LIU Yu-ling, LI Yan-qin (Jinzhou Medical College,Jinzhou 121001 China);Experimental Study on Effect of Eclipta Prostrata L on Thymocyte Apoptosis Induced with Cyclophosphamide[J];Journal of Jinzhou Medical College;2004-05
10 GAO Yi-jun, LING Tian-you. YIN Xiao-min,YAO Zhi-gang,TANG Jie -qing.Department of Stomatology,Second Xianya Hospital,Central South University Changsha 410011, China;A retrospective study for the malignant transformation of oral submucous fibrosis[J];Journal of Clinical Stomatology;2005-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 CHEN Jun, ZHOU Qinghua, QIN Yang, SUN Zhilin, SUN Zefang, WANG Yun, LI Lu, QIN Jianjun. Department of Thoracocardiac Surgery, The First University Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041, P.R.China;A study on transcript abnormalities of FHIT gene in human non small cell lung cancer[J];CHINESE JOURNAL OF LUNG CANCER;2000-04
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