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《Carcinogenesis,Teratogenesis & Mutagenesis》 2007-04
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Experimental Study on Anti-tumor Effects of Intracellular Polysaccharide from Phellinus Linteus

SHEN Ye-shou,ZHENG Li-jun,WANG Zheng-liang,GU Li-ping(Laboratory of Glycoconjugate and Glycotechnology, Institute of Biochemistry and Microbiology, Anhui University, Hefei 230039,Anhui, China)  
BACKGROUND AIM: To study the anti-tumor effects, efficacy enhancement and immunoregulatory function of intracellular polysaccharide(IPS) from liquid state fermentation of Phellinus linteus in S180-bearing mouse and provide evidence for exploring IPS. MATERIALS AND METHODS: S180-bearing mice were divided into 9 groups (10 mice per group) which were normal group, tumour-bearing group, Cyclophosphamide(CP) group, IPS (50, 100, 200 mg/kg) groups and co-administration groups of IPS(50,100,200 mg/kg) with CP. The anti-tumor effects and the influences on immunity function of both IPS and co-administration of IPS with CP were observed. The MTT method was used to measure the proliferation activity of splenic lymphocytes of S180-bearing mouse. RESULTS: At doses of 200 and 100 mg/kg, inhibition rates of S180 sarcoma were 57.02% and 61.40% respectively. The inhibition rate of co-administration of 100 mg/kg IPS with CP could reach 79.51%. IPS significantly increased thymus index and spleen index of S180-bearing mouse and protect the immune organs aginst CP. IPS promoted the growth of leucocytes and inhibited its reduction induced by CP. Besides, IPS enhanced cell-mediated immunity by accelerating T-cell proliferation. CONCLUSION: IPS of Phellinus linteus was shown to have significant anti-tumor effects and promoted the immune function of tumor-bearing mice. IPS could also mitigate the toxic and side effects of chemotherapeutic agents and enhancing the efficacy of CP.
【CateGory Index】: R285.5
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