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《Carcinogenesis,Teratogenesis & Mutagenesis》 2007-05
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Relationship Between Expressions of MT-3 and MDR-1 in Bladder Cancer

ZHU Bin,YANG Luo-yan,ZHAO Xiao-kun(Department of Urology,Xiangya Second Hospital of Central South University,Changsha 410011,China)  
BACKGROUND AIM:To investigate the role of MT-3 in transitional cell carcinomas of bladder and the possible relation with MDR-1.MATERIALS AND METHODS:Using RT-PCR technique,the expressions of MT-3 and MDR-1 mRNA in 11 specimens from normal bladder mucosa and 23 specimens from bladder transitional cell cancer(BTCC)were measured.RESULTS:MT-3 and MDR-1-positive expression rates were found in 0 and 9.1% in normal bladder mucosa,respectively.But they were 78.3% and 56.5% in 23 BTCC specimens,respectively.The positive rate was significantly higher in BTCC specimens than in normal tissue(P0.05).The expressions of MT-3 and MDR-1 were not related with the grade,stage and recurrence after postoperative intravesical chemotherapy.CONCLUSION:MT-3 mRNA could not be identified in normal bladder mucosa,but highly expressed in bladder neoplasm,MT-3 might be used as a tumor marker.
【CateGory Index】: R737.14
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