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《Carcinogenesis,Teratogenesis & Mutagenesis》 2007-06
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Detection of Antimutagenicity of Puerarin by TK Gene Mutation Test

DING Xiao-qin1,CHEN Jie2,ZHANG Li-shi1,(1.Department of Nutrition and Food Hygiene,West China School of Public Health,Sichuan University,Chengdu 610041;2.South Western University of Finance and Economics,Chengdu610074,China)  
BACKGROUND AIM:To detect and evaluate the antimutagenicity of puerarin by TK gene mutation test.MATERIALS AND METHODS:The TK6 human lymphoid cells were exposed to puerarin at concentrations of 25,50,100 μg/ml with 5 μg/ml MMS,0.1% DMSO,5 μg/ml MMS and 5 μg/ml MMS+100 μg/ml VitC using simultaneous treatment to determine PE0,PE3,RSG and TMF.RESULTS:Puerarin at concentration 100 μg/ml significantly decreased the TMF induced by MMS.CONCLUSION:Under this experimental condition,puerarin inhibited TK gene mutation on TK6 cell induced by MMS at higher concentration,and has good potential for further development and application.
【Fund】: 国家自然科学基金(30471473)
【CateGory Index】: R285
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