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《Carcinogenesis,Teratogenesis & Mutagenesis》 2007-06
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Effects of Chitosan Oligosaccharide and Bifidobacteria on Immune Function in Tumor-bearing Mice

GUAN Jie,WU Yan-min,WANG Hui,QIAN Li-li,Li Dian-jun,(Department of Immunology,Qiqihaer Medical College,Qiqihaer 161042,China)  
BACKGROUND AIM:Establish the tumor animal model of the H22 liver cancer in mice,and study the inhibition effects of chitosan oligosaccharide and bifidobacteria on the tumor.MATERIALS AND METHODS:Chitosan oligosaccharide and bifidobacteria were injected into tumor-bearing mice,the growth and pathological changes of the tumor were examined;and the immunological functions were measured.RESULTS:Growth of tumor were inhibited by chitosan oligosaccharide and bifidobacteria.They could increase the content of IL-2 and IFN-γ and the weights of spleen and thymus of the mice.Necrosis was observed in the tumor tissue.CONCLUSION:Chitosan oligosaccharide and bifidobacteria could inhibit the growth of tumor,improve immunity and induce tumor necrosis.
【Fund】: 黑龙江省教育厅科学技术研究面上项目(11511457)
【CateGory Index】: R73-3
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