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Establishment of an Acute Aging Model in Mice Induced by γ-ray Irradiation

YANG Xue-kang,HAI Chun-xu,LIANG Xin,ZHAO Hai-long,BAI Hua.(Department of Toxicology,the Fourth Military Medical University,Xi'an 710033,China)  
BACKGROUND AIM:To establish a convenient acute aging model by γ-ray irradiation.MATERIALS AND METHODS:45 mice were divided into 3 groups:the control group,the model 1 group irradiated by 3 Gy×8 times and the model 2 group irradiated by 6 Gy×4 times.Complete blood count,thymus weight index,spleen weight index,activity of SOD,the contents of MDA and lipofuscin were determined.The expression of β-galactosidase was evaluated by staining at the end of 50 days experiment.RESULTS:Compared with control group,the complete blood count,thymus weight index and spleen weight index all decreased(P0.05),the activity of SOD also decreased(P0.05),but the contents of MDA and lipofuscin were increased(P0.05).The β-galactosidase activity of hepatic cells was enhanced in the aging mice model.CONCLUSION:The acute aging model by γ-ray irradiation was successfully established,and it was a feasible method.
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