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《Carcinogenesis,Teratogenesis & Mutagenesis》 2008-02
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Studies on the Acute Toxicity and the Mutagenicity of Flavonoids Extracts

CHEN Cun-wu,CHEN Nai-fu,ZHANG Li,ZHOU Yong-bao,LI Yang(Department of Chemistry and Life Science,West Anhui University,Lu'an 237012,Anhui,China)  
BACKGROUND AND AIM:To study the acute toxicity and the mutagenicity of the flavonoids extracted from pteridium aquilinum var.latiusculum.MATERIALS AND METHODS:The oral acute toxicity test,micronucleus test of bone marrow PCE cell and sperm shape abnormality test were carried out.RESULTS:LD50 of the flavonoids extracts from pteridium aquilinum var.latiusculum in rats was more than 20.0 g/kg.The micronucleus rates and sperm abnormality rates in all doses were negative(P0.05).CONCLUSION:The flavonoids extracted from pteridium aquilinum var.latiusculum was considered a substance with no toxicity and mutagenic activity in this study.
【Fund】: 安徽省高校省级自然科学研究重点资助项目(2006KJ064A)
【CateGory Index】: R285
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