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《Carcinogenesis,Teratogenesis & Mutagenesis》 2008-03
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Long-term(12-week)Toxicity Test on Dogs with Selenium-enriched garlic

LIN Fei, LIANG Yi, LU Lian, CHEN Zhen, GAO Feng-ming, YANG Wen-jie, HAN Wen-hai(National Institute for Control of Pharmaceutical andBiological Products, Beijing 100050, China)  
BACKGROUND AND AIM: To evaluate the toxic reactions and severity in dogs fed continuously with selenium-enriched garlic. MATERIALS AND METHODS: Wistar dogs were divided into four groups (3.00 g/kg、1.50 g/kg、0.75 g/kg and a solvent control), fed continually for 12 weeks and observed for 2 weeks after stopping the medicine. General condition, haematology and biochemical tests, electrocardiogram, urine test, visceral dissection and coefficient and histopathology were performed. RESULTS: Dogs in the high dose group vomited intermittently, and appetite was decreasd. Serum total bilirubin was obviously increased, the albumin lowered, the coefficients of thymus gland and spleen went up. No other toxics reactions were observed. CONCLUSION: The selenium-enriched garlic was a mild alimentary tract stimulant with obvious increase in the serum total bilirubin, at 30 times the clinical dose. The dose of 0.75 g/kg in dogs had no obvious toxicity reaction.
【Fund】: 国家自然科学基金(30471454)
【CateGory Index】: R96
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